Analysis of Carvedilol in Pharmaceutical Preparations by Spectrofluorometric Method

The goal of this research is to develop a spectrofluorometric method for analyzing carvedilol in pharmaceutical preparations and apply this method to the formulations. The method’s calibration curve was plotted between 25 and 500 ng/mL. The mean calibration equation from six replicate experiments is y=1.8736x+7.7291. The correlation coefficient value was higher than 0.997 for the mean calibration curve. The trueness results were better than 2.09% and the precision results were less than 2.73% for carvedilol. The detection and quantitation limits were determined as 2.196 and 6.654 ng/mL, respectively. In addition, the method was used to study carvedilol in pharmaceutical preparations. The method had recovery values >98.4% for all samples in pharmaceutical preparations. The detection wavelength was optimized to maximize the sensitivity of the method. This method has good sensitivity with satisfactory results. Therefore, the method can be used in carvedilol analysis.