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Do we know enough to find an adjunctive therapy for cerebral malaria in African children?
- Source :
- F1000Research
- Publication Year :
- 2017
-
Abstract
- Cerebral malaria is the deadliest complication of malaria, a febrile infectious disease caused by Plasmodium parasite. Any of the five human Plasmodium species can cause disease, but, for unknown reasons, in approximately 2 million cases each year P. falciparum progresses to severe disease, ultimately resulting in half a million deaths. The majority of these deaths are in children under the age of five. Currently, there is no way to predict which child will progress to severe disease and there are no adjunctive therapies to halt the symptoms after onset. Herein, we discuss what is known about the disease mechanism of one form of severe malaria, cerebral malaria, and how we might exploit this understanding to rescue children in the throes of cerebral disease.
- Subjects :
- 0301 basic medicine
Pediatrics
medicine.medical_specialty
Plasmodium
Plasmodium falciparum
Tropical & Travel-Associated Diseases
Disease
Review
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Anesthesiology
parasitic diseases
Medicine
General Pharmacology, Toxicology and Pharmaceutics
Immunity to Infections
Plasmodium species
General Immunology and Microbiology
biology
business.industry
Pediatric Infectious Diseases
General Medicine
Articles
medicine.disease
biology.organism_classification
Innate Immunity
030104 developmental biology
Cerebral Malaria
Infectious disease (medical specialty)
Medical Microbiology
Immunology
Parasitology
business
Complication
Malaria
Subjects
Details
- ISSN :
- 20461402
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- F1000Research
- Accession number :
- edsair.doi.dedup.....a5a7abcb991f989610448b446164dd12