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Association between systemic inflammation and water composition and survival in colorectal cancer

Association between systemic inflammation and water composition and survival in colorectal cancer

Authors :
Shi-Qi, Lin
Hai-Lun, Xie
Yi-Zhong, Ge
Guo-Tian, Ruan
Qi, Zhang
Meng-Meng, Song
He-Yang, Zhang
Xi, Zhang
Xiang-Rui, Li
Meng, Tang
Xian, Shen
Chun-Hua, Song
Wei, Li
Han-Ping, Shi
Source :
Frontiers in Oncology. 12
Publication Year :
2022
Publisher :
Frontiers Media SA, 2022.

Abstract

BackgroundSystemic inflammation and water composition are important factors affecting cancer prognosis. This study aimed to explore the association between the neutrophil-to-lymphocyte ratio (NLR) and intracellular water/total body water (ICW/TBW) ratio and overall survival (OS) in colorectal cancer (CRC).MethodsThis multicenter, prospective cohort included 628 patients with CRC between June 2012 and December 2019. The association between the covariates and OS was assessed using a Cox proportional hazards model and restricted cubic spline models. Concordance index (C-index), which integrated discriminant improvement (IDI) index and continuous net reclassification index, (cNRI) was used to compare the predictive ability of the markers.ResultsThe optimal cutoff values for the NLR and ICW/TBW ratio were 2.42 and 0.61, respectively. The NLR was negatively associated with OS, while the ICW/TBW ratio was positively correlated with OS. NLR ≥2.42 and ICW/TBW ratio ConclusionA high NLR and a low ICW/TBW ratio were independent risk factors for poor prognosis in patients with CRC. The combination of the two factors can provide a better prognostic prediction effect.

Subjects

Subjects :
Cancer Research
Oncology

Details

ISSN :
2234943X
Volume :
12
Database :
OpenAIRE
Journal :
Frontiers in Oncology
Accession number :
edsair.doi.dedup.....a5ac621e82e70cc436db6a941dc86ea3
Full Text :
https://doi.org/10.3389/fonc.2022.896160