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Long-term alterations in somatosensory functioning in survivors of childhood cancer
- Source :
- Pain. 163(6)
- Publication Year :
- 2021
-
Abstract
- Cancer and its treatment can have lasting consequences on somatosensation, including pain, which is often underrecognized and undertreated. Research characterizing the impact of cancer on pain and sensory processing in survivors of childhood cancer is scarce. This study aimed to quantify generalized differences in pain and sensory processing in survivors of childhood cancer compared with reference data using a standardized thermal and mechanical quantitative sensory testing (QST) protocol. The association between demographic, clinical (eg, leukemia vs other cancers and treatment exposures), and psychosocial (eg, anxiety and pain catastrophizing) variables and sensitivity to pain and sensory stimuli were also evaluated. Participants were 56 survivors of various types of childhood cancer (52% male, Mage = 13.5 years, SD = 3.2, range = 8-17 years). On average, children were 7 years (SD = 4.1, range = 1.2-16.5) post treatment. Almost all participants (86%) had at least 1 abnormal QST parameter compared with age- and sex-matched reference data; however, few participants self-reported the presence of sensory abnormalities. Generally, participants exhibited reduced sensitivity across the QST parameters examined (Ps < 0.05, ds = 0.40-3.45). A significant minority (45%) also exhibited pain sensitization (P
- Subjects :
- Male
Pain Threshold
Vincristine
medicine.medical_specialty
Sensory processing
medicine.medical_treatment
Population
Pain
Cancer Survivors
Internal medicine
Neoplasms
Medicine
Humans
Survivors
education
Child
education.field_of_study
Leukemia
business.industry
Cumulative dose
Cancer
medicine.disease
Anesthesiology and Pain Medicine
Neurology
Anxiety
Pain catastrophizing
Female
Neurology (clinical)
medicine.symptom
business
Psychosocial
medicine.drug
Subjects
Details
- ISSN :
- 18726623
- Volume :
- 163
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Pain
- Accession number :
- edsair.doi.dedup.....a5eeb06a9a55e4eee531bb6dac665371