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Changes in articular cartilage in experimentally induced patellar subluxation
- Publication Year :
- 1997
-
Abstract
- OBJECTIVES Patellar subluxation was experimentally induced in young rabbits and the resulting cartilaginous changes were observed over a prolonged period of time to determine histological changes in the subluxated patellar cartilage. METHODS The tibial tuberosity in 12 week old rabbits was laterally displaced and fixed to the tibia with wire to induce lateral patellar subluxation. Pathological changes in patellar cartilage were examined for 120 weeks after surgery using computed tomography and stereoscopic microscopy. RESULTS Eight weeks after surgery, changes in articular cartilage consisting of horizontal splitting of the matrix were observed in the intermediate zone and were presumed to have been caused by shearing stress applied to the patellar cartilage. The cartilaginous changes caused by patellar subluxation progressed very little over the 120 weeks. Very few rabbits presented with osteoarthritic changes in the patellofemoral joint, most probably because the stress resulting from the malalignment of the patellofemoral joint was mild enough to permit recovery. CONCLUSION The mild, non-progressive pathological changes, in particular, basal degeneration, induced in this experiment in patellar cartilage were quite similar to the changes in articular cartilage seen in human chondromalacia patellae.
- Subjects :
- musculoskeletal diseases
Cartilage, Articular
Immunology
Joint Dislocations
Hindlimb
Osteoarthritis
Chondromalacia patellae
General Biochemistry, Genetics and Molecular Biology
Extended Reports
Rheumatology
Arthropathy
medicine
Immunology and Allergy
Animals
Tibia
Joint dislocation
skin and connective tissue diseases
business.industry
Anatomy
Patella
medicine.disease
musculoskeletal system
Chondromalacia
Disease Models, Animal
Female
sense organs
Rabbits
business
Cartilage Diseases
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a602a462b8fcd1b04d2968a80b46c38f