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Synapsins regulate α-synuclein functions
- Source :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Year :
- 2019
- Publisher :
- National Academy of Sciences, 2019.
-
Abstract
- The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.
- Subjects :
- animal diseases
Attenuator (genetics)
Neurotransmission
Biology
Synaptic vesicle
Cell Line
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
alpha synuclein
Animals
heterocyclic compounds
neurotransmission
030304 developmental biology
Alpha-synuclein
synapsin
Neurons
0303 health sciences
Multidisciplinary
Synapsin
Biological Sciences
Synapsins
Cell biology
nervous system diseases
Cytosol
chemistry
nervous system
Synapses
health occupations
alpha-Synuclein
α synuclein
Synaptic Vesicles
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 10916490 and 00278424
- Volume :
- 116
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....a62a4f4771db8ccc7467cee78c8f59f9