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EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients
- Source :
- Journal of hepatology, Netherlands, Journal of Hepatology
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- According to a recent World Health Organization estimate, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which originated in China in 2019, has spread globally, infecting nearly 100 million people worldwide by January 2021. Patients with chronic liver diseases (CLD), particularly cirrhosis, hepatobiliary malignancies, candidates for liver transplantation, and immunosuppressed individuals after liver transplantation appear to be at increased risk of infections in general, which in turn translates into increased mortality. This is also the case for SARS-CoV-2 infection, where patients with cirrhosis, in particular, are at high risk of a severe COVID-19 course. Therefore, vaccination against various pathogens including SARS-CoV-2, administered as early as possible in patients with CLD, is an important protective measure. However, due to impaired immune responses in these patients, the immediate and long-term protective response through immunisation may be incomplete. The current SARS-CoV-2 pandemic has led to the exceptionally fast development of several vaccine candidates. A small number of these SARS-CoV-2 vaccine candidates have already undergone phase III, placebo-controlled, clinical trials in healthy individuals with proof of short-term safety, immunogenicity and efficacy. However, although regulatory agencies in the US and Europe have already approved some of these vaccines for clinical use, information on immunogenicity, duration of protection and long-term safety in patients with CLD, cirrhosis, hepatobiliary cancer and liver transplant recipients has yet to be generated. This review summarises the data on vaccine safety, immunogenicity, and efficacy in this patient population in general and discusses the implications of this knowledge on the introduction of the new SARS-CoV-2 vaccines.
- Subjects :
- medicine.medical_specialty
COVID-19 Vaccines
Cirrhosis
Coronavirus disease 2019 (COVID-19)
medicine.medical_treatment
Liver transplantation
Immunocompromised Host
Pandemic
Humans
Medicine
Intensive care medicine
Letter to the Editor
Hepatology
business.industry
SARS-CoV-2
Liver Diseases
Immunogenicity
Vaccination
COVID-19
medicine.disease
Influenza
Clinical trial
Biliary Tract Neoplasms
Position paper
Risk Adjustment
business
Vaccine
Liver Transplantation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of hepatology, Netherlands, Journal of Hepatology
- Accession number :
- edsair.doi.dedup.....a637adf0e0130f0708d1945b2b86abdf