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Helper T cells in malignant pleural effusion
- Source :
- Cancer Letters. 500:21-28
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Malignant pleural effusion (MPE) is a frequent complication of malignancies and poses a clinical problem. CD4+ T lymphocytes are the most frequent cell population in MPE. Traditionally, CD4+ T cells are classified into two subsets based on cytokine production profiles, type 1 (Th1) and type 2 (Th2) helper T cells, which exhibit distinct functions. Recently, other T-cell subsets have been added to the Th-cell “portfolio”, including regulatory T, Th17, Th9, and Th22 cells. The current review focuses on summarizing the Th-cell phenotypic characteristics, mechanism of Th-cell differentiation, and their pleural space recruitment, based on recent research. We also describe the interplay in MPE among different Th cells, as well as Th cells and lung cancer cells or mesothelial cells. Future research should expand the landscape map of human MPE immune cells, explore the immuno-regulation of B cells, and investigate the communication between macrophages and Th cells in MPE, which may facilitate meaningful advancements in the diagnoses and therapeutics of MPE.
- Subjects :
- CD4-Positive T-Lymphocytes
0301 basic medicine
Cancer Research
medicine.medical_treatment
Population
Cell
Biology
Lymphocyte Activation
T-Lymphocytes, Regulatory
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Immune system
T-Lymphocyte Subsets
medicine
Humans
Malignant pleural effusion
Lung cancer
education
B-Lymphocytes
education.field_of_study
Interleukin-17
Cell Differentiation
T-Lymphocytes, Helper-Inducer
Th1 Cells
medicine.disease
Phenotype
Pleural Effusion, Malignant
030104 developmental biology
medicine.anatomical_structure
Cytokine
Oncology
A549 Cells
030220 oncology & carcinogenesis
Cancer research
Th17 Cells
Signal Transduction
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 500
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....a63fe071ab7ba3ddff565eff2d6a1d36