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Central nervous system lymphoma: patterns of incidence in Indian population and effect of steroids on stereotactic biopsy yield
- Source :
- Neurology India. 62(1)
- Publication Year :
- 2014
-
Abstract
- Background: Epidemiology of primary central nervous system lymphoma (PCNSL) world-wide shows an increase in incidence linked to human immunodeficiency virus (HIV) pandemic. Materials and Methods: This retrospective review of case records analyzed the trends of hospital-based incidence of PCNSL over two decades (1991-2010), relation to immune status and effect of steroids on yield of stereotactic biopsy (STB). Results: A total of 76 cases of PCNSL were diagnosed over a period of two decades. Incidence of lymphomas amongst all biopsied lesions showed a gradual increase from 0.18% at the beginning of study period to 0.41% at the end of study period. Only 8.6% (3 of 35 tested) of the PCNSL patients were positive for HIV. The mean age of patients with HIV infection (31.3 ± 3.5 years) was significantly lower compared with those without HIV infection (44.7 ± 10.9 years) (P = 0.033). Diagnosis was obtained by open biopsy in 32 patients (42.1%) and STB in 44 patients (57.9%). Open biopsy yielded a histological confirmation of PCNSL in all cases. Among those who underwent STB, the incidence of negative biopsy with short duration of steroids (≤1 week) was 33.3% and increased to 57.1% with increasing duration of steroid treatment (>1 week). Conclusions: This study documented an increase in hospital based incidence of PCNSL in our institute, independent of HIV association. Steroid intake administration for more than a week prior to biopsy adversely affected the yield of STB in PCNSL.
- Subjects :
- Adult
Male
medicine.medical_specialty
Stereotactic biopsy
Open biopsy
Time Factors
Adolescent
Lymphoma
India
HIV Infections
Comorbidity
Gastroenterology
Central Nervous System Neoplasms
Stereotaxic Techniques
Young Adult
hemic and lymphatic diseases
Internal medicine
Biopsy
medicine
Humans
Aged
Retrospective Studies
medicine.diagnostic_test
business.industry
Incidence (epidemiology)
Incidence
Primary central nervous system lymphoma
Retrospective cohort study
Middle Aged
medicine.disease
Surgery
Neurology
Stereotaxic technique
Female
Steroids
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 00283886
- Volume :
- 62
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neurology India
- Accession number :
- edsair.doi.dedup.....a646c60f1fbcca5e3aaaf5bd26a5b94d