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Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period
- Source :
- J Infect Dis
- Publication Year :
- 2018
-
Abstract
- Background The durability and breadth of human immunodeficiency virus type 1 (HIV-1)–specific immune responses elicited through vaccination are important considerations in the development of an effective HIV-1 vaccine. Responses to HIV-1 envelope subunit protein (Env) immunization in humans are often described as short-lived. Methods We enrolled 16 healthy volunteers who had received priming with an HIV-1 subtype B Env vaccine given with MF59 adjuvant 5–17 years previously and 20 healthy unprimed volunteers. Three booster immunizations with a heterologous subtype C trimeric gp140 protein vaccine were administered to the primed group, and the same subtype C gp140 protein vaccination regimen was administered to the unprimed subjects. Results Binding antibodies and neutralizing antibodies to tier 1 viral isolates were detected in the majority of previously primed subjects. Remarkably, a single dose of protein boosted binding and neutralizing antibody titers in 100% of primed subjects following this prolonged immunologic rest period, and CD4+ T-cell responses were boosted in 75% of primed individuals. Conclusions These results demonstrate that HIV-1 protein immunogens can elicit durable memory T- and B-cell responses and that strong tier 1 virus neutralizing responses can be elicited by a single booster dose of protein following a long immunologic rest period. However, we found no evidence that cross-clade boosting led to a significantly broadened neutralizing antibody response.
- Subjects :
- Adult
Adolescent
medicine.medical_treatment
MF59
Immunization, Secondary
HIV Infections
Booster dose
HIV Antibodies
Young Adult
Major Articles and Brief Reports
Antigen
Adjuvants, Immunologic
Immunology and Allergy
Medicine
Humans
HIV vaccine
Neutralizing antibody
biology
business.industry
Vaccination
Middle Aged
Antibodies, Neutralizing
Infectious Diseases
Immunology
biology.protein
HIV-1
Antibody
business
Adjuvant
Subjects
Details
- ISSN :
- 15376613
- Volume :
- 219
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....a65859efa7f56b361b9028a6962e6139