The alpha-Gal syndrome is a tick-associated and emerging IgE-mediated hypersensitivity reaction directed against the carbohydrate Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal) epitope after red meat intake. Herein, we describe a clinical case of a 44-year-old French patient who suffered from recurrent anaphylactic reactions after mammalian meat consumption for five years before the final diagnosis of the alpha-Gal syndrome was established in 2018. The patient also reported multiple tick bites prior to symptom onset. This unique type of allergy has increasingly been reported across the world, but it is still unknown in many European countries. Therefore, the present clinical case should increase awareness among primary care practitioners and further improve the early diagnosis of the alpha-Gal syndrome in affected individuals

The α-Gal syndrome is a tick-associated and emerging IgE-mediated hypersensitivity reaction directed against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) epitope after red meat intake. Herein, we describe a clinical case of a 44-year-old French patient who suffered from recurrent anaphylactic reactions after mammalian meat consumption for five years before the final diagnosis of the α-Gal syndrome was established in 2018. The patient also reported multiple tick bites prior to symptom onset. This unique type of allergy has increasingly been reported across the world, but it is still unknown in many European countries. Therefore, the present clinical case should increase awareness among primary care practitioners and further improve the early diagnosis of the α-Gal syndrome in affected individuals.
El síndrome de α-Gal es una reacción de hipersensibilidad mediada por IgE emergente y asociada a garrapatas dirigida contra el epítopo de carbohidratos Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) después de la ingesta de carne roja. En este documento, describimos un caso clínico de un paciente francés de 44 años que sufrió reacciones anafilácticas recurrentes después del consumo de carne de mamífero durante cinco años antes de que se estableciera el diagnóstico final del síndrome α-Gal en 2018. El paciente también informó múltiples garrapatas. muerdeantes del inicio de los síntomas. Este tipo único de alergia se ha informado cada vez más en todo el mundo, pero aún se desconoce en muchos países europeos. Por lo tanto, el presente caso clínico debería aumentar la conciencia entre los médicos de atención primaria y mejorar aún más el diagnóstico precoz del síndrome de α-Gal en las personas afectadas.