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Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites

Authors :
Jing Wu
Takeru Ohura
Ryuhei Ogura
Junhong Wang
Jae-Hoon Choi
Hajime Kobori
Corina N. D’Alessandro-Gabazza
Masaaki Toda
Taro Yasuma
Esteban C. Gabazza
Yuichi Takikawa
Hirofumi Hirai
Hirokazu Kawagishi
Source :
Antibiotics; Volume 12; Issue 3; Pages: 596
Publication Year :
2023
Publisher :
MDPI, 2023.

Abstract

A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R. This is the first time that compounds 2–4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptobacterium carotovorum, Clavibacter michiganensis and Burkholderia glumae, compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis. In the bioassay to examine plant growth regulatory activity, compounds 1–4 showed a significant regulatory activity on lettuce growth.

Details

Language :
English
ISSN :
20796382
Volume :
12
Issue :
3
Database :
OpenAIRE
Journal :
Antibiotics
Accession number :
edsair.doi.dedup.....a672e2a3fe6fbe30dc2b5d8a97e13586