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Evaluation of the interference of lamotrigine on the analysis of synthetic cannabinoids in urine by the immunoassay method
- Source :
- Scandinavian Journal of Clinical and Laboratory Investigation. 81:532-539
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- We aimed to evaluate the interference of lamotrigine (LMG) on the synthetic cannabinoids metabolite-K2/1 (SCm/K1) urine test by Homogeneous Enzyme Immunoassay (Immune-SCm/K1). This study consists of two parts: case-control and interference effect research. In the case-control study, two groups using LMG and a non-use of LMG were formed, all of them non-SC users. In the interference effect research, four groups were formed by adding either a LMG stock solution or a LMG user's urine to a SCm/K1 negative urine, and Immune-SCm/K1 test calibrators and quality control (QC) materials. Immune-SCm/K1, SCm/K1 by LC/MS-MS and LMG tests were performed on all samples in the study. The case-control study was performed on a total of 55 participants (mean age 39.76 ± 9.84 years). Both groups were statistically insignificant in terms of age and gender. Urine LMG levels were 5.71 ± 10.61 mg/L in the LMG group and0.30 mg/L in the control group. Immune-SCm/K1 results were 35.84 ± 7.62 ng/mL in the LMG group,3.00 ng/mL in the control group and the LC/MS-SCm/K1 urine test of both groups were found to be 'NEGATIVE'. Results were interpreted as a cross-reaction in the interference study and a statistically significant relationship was found between LMG levels and Immune-SCm/K1 levels in the SCm/K1 negative samples (groups 1 and 2) (
- Subjects :
- Adult
Male
Adolescent
Clinical Biochemistry
Urine
Lamotrigine
Young Adult
Interference (communication)
Synthetic cannabinoids
medicine
Humans
Immunoassay
Chromatography
medicine.diagnostic_test
Cannabinoids
Chemistry
fungi
food and beverages
General Medicine
Middle Aged
JWH-018
Immunoassay method
Homogeneous
Case-Control Studies
Metabolome
Regression Analysis
Female
medicine.drug
Subjects
Details
- ISSN :
- 15027686 and 00365513
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Clinical and Laboratory Investigation
- Accession number :
- edsair.doi.dedup.....a693f3032bc8d65076ff2014f0882b56
- Full Text :
- https://doi.org/10.1080/00365513.2021.1961855