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Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers
- Source :
- Journal of Experimental Medicine, Journal of Experimental Medicine, 2020, 217 (10), pp.e20200840. ⟨10.1084/jem.20200840⟩, Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (10), pp.e20200840. ⟨10.1084/jem.20200840⟩
- Publication Year :
- 2020
- Publisher :
- Rockefeller University Press, 2020.
-
Abstract
- International audience; Rare individuals can naturally clear chronic hepatitis B virus (HBV) infection and acquire protection from reinfection as conferred by vaccination. To examine the protective humoral response against HBV, we cloned and characterized human antibodies specific to the viral surface glycoproteins (HBsAg) from memory B cells of HBV vaccinees and controllers. We found that human HBV antibodies are encoded by a diverse set of immunoglobulin genes and recognize various conformational HBsAg epitopes. Strikingly, HBsAg-specific memory B cells from natural controllers mainly produced neutralizing antibodies able to cross-react with several viral genotypes. Furthermore, monotherapy with the potent broadly neutralizing antibody Bc1.187 suppressed viremia in vivo in HBV mouse models and led to post-therapy control of the infection in a fraction of animals. Thus, human neutralizing HBsAg antibodies appear to play a key role in the spontaneous control of HBV and represent promising immunotherapeutic tools for achieving HBV functional cure in chronically infected humans.
- Subjects :
- 0301 basic medicine
HBsAg
MESH: Epitopes
MESH: Hepatitis B, Chronic
Immunology
MESH: Flow Cytometry
Viremia
medicine.disease_cause
Epitope
Virus
MESH: Antibodies, Neutralizing
MESH: Cross Reactions
03 medical and health sciences
[SDV.IMM.VAC] Life Sciences [q-bio]/Immunology/Vaccinology
0302 clinical medicine
MESH: B-Lymphocytes
medicine
Immunology and Allergy
MESH: Animals
MESH: Mice
Hepatitis B virus
MESH: Hepatitis B Vaccines
MESH: Humans
MESH: Hepatitis B
biology
MESH: Neutralization Tests
MESH: Enzyme-Linked Immunosorbent Assay
virus diseases
[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy
Hepatitis B
medicine.disease
Virology
digestive system diseases
MESH: Hepatitis B Surface Antigens
3. Good health
Vaccination
MESH: Hepatitis B virus
030104 developmental biology
MESH: Immunologic Memory
biology.protein
030211 gastroenterology & hepatology
[SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy
[SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology
Antibody
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 217
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....a697d51b530a4620f47509dfe4efb9fc