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Cholinergic modulation of spindle bursts in the neonatal rat visual cortex in vivo
- Source :
- Journal of Neuroscience, Journal of Neuroscience, 2007, 27 (21), pp.5694-705. ⟨10.1523/JNEUROSCI.5233-06.2007⟩, Journal of Neuroscience, Society for Neuroscience, 2007, 27 (21), pp.5694-705. ⟨10.1523/JNEUROSCI.5233-06.2007⟩
- Publication Year :
- 2007
- Publisher :
- HAL CCSD, 2007.
-
Abstract
- Acetylcholine (ACh) is known to shape the adult neocortical activity related to behavioral states and processing of sensory information. However, the impact of cholinergic input on the neonatal neuronal activity remains widely unknown. Early during development, the principal activity pattern in the primary visual (V1) cortex is the intermittent self-organized spindle burst oscillation that can be driven by the retinal waves. Here, we assessed the relationship between this early activity pattern and the cholinergic drive by either blocking or augmenting the cholinergic input and investigating the resultant effects on the activity of the rat visual cortex during the first postnatal weekin vivo. Blockade of the muscarinic receptors by intracerebroventricular, intracortical, or supracortical atropine application decreased the occurrence of V1 spindle bursts by 50%, both the retina-independent and the optic nerve-mediated spindle bursts being affected. In contrast, blockade of acetylcholine esterase with physostigmine augmented the occurrence, amplitude, and duration of V1 spindle bursts. Whereas direct stimulation of the cholinergic basal forebrain nuclei increased the occurrence probability of V1 spindle bursts, their chronic immunotoxic lesion using 192 IgG-saporin decreased the occurrence of neonatal V1 oscillatory activity by 87%. Thus, the cholinergic input facilitates the neonatal V1 spindle bursts and may prime the developing cortex to operate specifically on relevant early (retinal waves) and later (visual input) stimuli.
- Subjects :
- Male
medicine.medical_specialty
MESH: Rats
Cholinergic Agents
Sensory system
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Cholinergic Agonists
Biology
Synaptic Transmission
Cholinergic Antagonists
MESH: Animals, Newborn
03 medical and health sciences
0302 clinical medicine
Cortex (anatomy)
Internal medicine
medicine
MESH: Synaptic Transmission
Animals
Visual Pathways
MESH: Animals
MESH: Cholinergic Agents
MESH: Cholinergic Antagonists
Cholinergic neuron
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
Visual Cortex
030304 developmental biology
0303 health sciences
Basal forebrain
MESH: Visual Pathways
General Neuroscience
MESH: Visual Cortex
Articles
Receptors, Muscarinic
MESH: Male
Rats
Retinal waves
MESH: Cholinergic Fibers
medicine.anatomical_structure
Visual cortex
Endocrinology
Animals, Newborn
Cholinergic Fibers
MESH: Receptors, Muscarinic
MESH: Cholinergic Agonists
Cholinergic
Neuroscience
030217 neurology & neurosurgery
Acetylcholine
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 02706474 and 15292401
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroscience, Journal of Neuroscience, 2007, 27 (21), pp.5694-705. ⟨10.1523/JNEUROSCI.5233-06.2007⟩, Journal of Neuroscience, Society for Neuroscience, 2007, 27 (21), pp.5694-705. ⟨10.1523/JNEUROSCI.5233-06.2007⟩
- Accession number :
- edsair.doi.dedup.....a6a9b6e757ff301dec195a518c955cc6
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.5233-06.2007⟩