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Characterization of microbiota in acute leukemia patients following successful remission induction chemotherapy without antimicrobial prophylaxis
- Source :
- International microbiology : the official journal of the Spanish Society for Microbiology. 24(2)
- Publication Year :
- 2020
-
Abstract
- In the present study, we characterized the microbiomes of acute leukemia (AL) patients who achieved complete remission following remission induction chemotherapy (RIC) as outpatients, but who did not receive antimicrobials to treat or prevent febrile neutropenia. Saliva and stool samples from 9 patients with acute myeloid leukemia, 11 patients with acute lymphoblastic leukemia, and 5 healthy controls were subjected to 16S ribosomal RNA sequencing at baseline and at 3 months following RIC. Only patients who achieved remission at 3 months post-treatment were included. We excluded anyone who used antimicrobials within 2 months of enrollment or at any time during the study period. At baseline, the relative abundances of species of Prevotella maculosa (P=0.001), Megasphaera micronuciformis (P=0.014), Roseburia inulinivorans (P=0.021), and Bacteroides uniformis (P=0.004) in saliva and Prevotella copri (P=0.002) in the stools of controls were significantly higher than in AL patients. Following RIC, the relative abundances of Eubacterium sp. oral clone DO008 (P=0.012), Leptotrichia sp. oral clone IK040 (P=0.002), Oribacterium sp. oral taxon 108 (P=0.029), Megasphaera micronuciformis (P=0.016), TM7 phylum sp. oral clone DR034 (P
- Subjects :
- Microbiology (medical)
Adult
Male
medicine.medical_specialty
Saliva
Antineoplastic Agents
Microbiology
Gastroenterology
Prevotella melaninogenica
03 medical and health sciences
Feces
Young Adult
Internal medicine
Medicine
Humans
Phylogeny
030304 developmental biology
Aged
0303 health sciences
Acute leukemia
Mouth
Leptotrichia buccalis
Leukemia
biology
Bacteria
030306 microbiology
business.industry
Induction chemotherapy
Myeloid leukemia
Induction Chemotherapy
Middle Aged
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Female
business
Febrile neutropenia
Subjects
Details
- ISSN :
- 16181905
- Volume :
- 24
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International microbiology : the official journal of the Spanish Society for Microbiology
- Accession number :
- edsair.doi.dedup.....a6b319cbbd59eb74bd6061b44ba982e8