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Understanding Ocular Discomfort and Dryness Using the Pain Sensitivity Questionnaire
- Source :
- PloS one, vol 11, iss 5, Li, W; Graham, AD; & Lin, MC. (2016). Understanding ocular discomfort and dryness using the pain sensitivity questionnaire. PLoS ONE, 11(5). doi: 10.1371/journal.pone.0154753. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/2b05c4d2, PLoS ONE, PLoS ONE, Vol 11, Iss 5, p e0154753 (2016)
- Publication Year :
- 2016
- Publisher :
- eScholarship, University of California, 2016.
-
Abstract
- © 2016 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Purpose: To utilize the Pain Sensitivity Questionnaire (PSQ) to assess the influence of pain sensitivity on perceptions of ocular discomfort and dryness. Methods: Subjects completed a battery of questionnaires, including history of ocular and general health, contact lens wear history, the Ocular Surface Disease Index (OSDI) questionnaire, visual analog scale (VAS) 100-point rating scales to assess severity and frequency of average and end of day (EOD) discomfort and dryness, and the PSQ to assess pain sensitivity level. Masked subjects were then instructed to wear one inverted and one normally oriented soft contact lens contralaterally for 30 minutes to induce an inter-eye difference in comfort and dryness sensations. Subjects rated comfort and dryness in each eye on VAS every 5 minutes during contact lens wear. A slit lamp examination was performed to evaluate ocular surface health and to assess contact lens fit. Results: One hundred and fifty-three subjects (111 females, 42 males) completed the study. In separate models, a higher PSQ score was significantly associated with higher OSDI score (p = 0.002), lower average and EOD comfort (p = 0.005 and 0.001, respectively), and greater EOD dryness (p = 0.04). The minimum (0.14) and maximum (7.14) PSQ scores observed in our subject cohort (i.e., from the subjects who were the least and most sensitive to pain, respectively) corresponded to an estimated difference of 11 points on the OSDI, 20 points on the VAS scale for average comfort, 31 points for EOD comfort and 17 points for EOD dryness. In a mixed effects model, a higher PSQ score was significantly associated with a greater inter-eye difference in comfort (p = 0.013) and dryness (p = 0.010) during CL wear. Conclusions: Pain sensitivity influences perceptions of ocular discomfort and dryness, and should be taken into account when evaluating subjective assessments of these symptoms.
- Subjects :
- Questionnaires
Male
Hydrophilic
genetic structures
Physiology
Epidemiology
Sensory Physiology
lcsh:Medicine
Social Sciences
Dry Eye Syndromes
Pathology and Laboratory Medicine
0302 clinical medicine
Surveys and Questionnaires
Medicine and Health Sciences
Psychology
Ethnicities
Medicine
Ocular Surface Disease Index
Precision Medicine
lcsh:Science
Lens (Anatomy)
Multidisciplinary
Pain Research
Contact Lenses, Hydrophilic
Sensory Systems
Somatosensory System
Research Design
Cohort
Dryness
Sensory Perception
Female
Anatomy
medicine.symptom
Chronic Pain
Research Article
Adult
medicine.medical_specialty
Adolescent
Visual analogue scale
Contact Lenses
General Science & Technology
Ocular Anatomy
Pain
Research and Analysis Methods
Ethnic Epidemiology
Every 5 minutes
03 medical and health sciences
Young Adult
Signs and Symptoms
Ocular System
Diagnostic Medicine
Rating scale
Clinical Research
Humans
Eye Disease and Disorders of Vision
Survey Research
business.industry
lcsh:R
Neurosciences
Biology and Life Sciences
Pain Sensation
eye diseases
Contact lens
People and Places
030221 ophthalmology & optometry
Physical therapy
Eyes
lcsh:Q
Population Groupings
business
Head
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- PloS one, vol 11, iss 5, Li, W; Graham, AD; & Lin, MC. (2016). Understanding ocular discomfort and dryness using the pain sensitivity questionnaire. PLoS ONE, 11(5). doi: 10.1371/journal.pone.0154753. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/2b05c4d2, PLoS ONE, PLoS ONE, Vol 11, Iss 5, p e0154753 (2016)
- Accession number :
- edsair.doi.dedup.....a6bac41852795ffcd2a4129b91d810e3