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Oxytocin infusion from Day 10 after oestrus extends the luteal phase in non-pregnant cattle
- Source :
- Reproduction. 86:203-210
- Publication Year :
- 1989
- Publisher :
- Bioscientifica, 1989.
-
Abstract
- Oestrus was synchronized in 8 cyclic heifers by progesterone treatment (PRID), after which the animals were monitored for one control cycle to measure the inter-oestrous interval. Osmotic minipumps containing saline (controls, N = 3) or oxytocin (N = 5) were implanted subcutaneously on Day 10 of the second cycle, and removed 12 days later. Jugular venous blood samples were collected daily for measurement of progesterone, and every 2 days for oxytocin. In addition, blood samples were taken every 10 min from 1 h before to 3 h after minipump insertion for measurement of plasma 15-keto-13,14-dihydroprostaglandin-F-2 alpha (PGFM) and every 30 min over the same period for measurement of progesterone and oxytocin. The lengths of the first untreated cycle in both groups of heifers were 20.2 +/- 0.56 (mean +/- s.e.m.) days compared with 25.4 +/- 0.81 days after oxytocin treatment (P less than 0.001). Oxytocin plasma concentrations in treated animals rose from less than 10 pg/ml to 70-500 pg/ml by 2 h after the start of oxytocin infusion and remained elevated until treatment was withdrawn. There was no increase in PGFM concentrations immediately after minipump insertion. Plasma progesterone concentrations were similar in treated and control animals but remained at mid-luteal levels for an average of 5 days longer in treated heifers. It is concluded that continuous administration of oxytocin can extend the luteal life-span in cattle.
- Subjects :
- Embryology
medicine.medical_specialty
medicine.medical_treatment
Alpha (ethology)
Luteal Phase
Biology
Luteal phase
Dinoprost
Oxytocin
Endocrinology
Internal medicine
medicine
Animals
Saline
Progesterone
Estrous cycle
Obstetrics and Gynecology
Radioimmunoassay
Cell Biology
Venous blood
medicine.anatomical_structure
Reproductive Medicine
Cattle
Female
Corpus luteum
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 17417899 and 14701626
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Reproduction
- Accession number :
- edsair.doi.dedup.....a6d4d469549e247765d6bc9acfcccd81