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Impact of the diet on net endogenous acid production and acid–base balance
- Source :
- Clinical Nutrition, Clinical Nutrition, Elsevier, 2012, 31 (3), pp.313-321. ⟨10.1016/j.clnu.2012.01.006⟩
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- International audience; Net acid production, which is composed of volatile acids (15,000 mEq/day) and metabolic acids (70-100 mEq/day) is relatively small compared to whole-body H+ turnover (150,000 mEq/day). Metabolic acids are ingested from the diet or produced as intermediary or end products of endogenous metabolism. The three commonly reported sources of net acid production are the metabolism of sulphur amino acids, the metabolism or ingestion of organic acids, and the metabolism of phosphate esters or dietary phosphoproteins. Net base production occurs mainly as a result of absorption of organic anions from the diet. To maintain acid-base balance, ingested and endogenously produced acids are neutralized within the body by buffer systems or eliminated from the body through the respiratory (excretion of volatile acid in the form of CO2) and urinary (excretion of fixed acids and remaining H+) pathways. Because of the many reactions involved in the acid-base balance, the direct determination of acid production is complex and is usually estimated through direct or indirect measurements of acid excretion. However, indirect approaches, which assess the acid-forming potential of the ingested diet based on its composition, do not take all the acid-producing reactions into account. Direct measurements therefore seem more reliable. Nevertheless, acid excretion does not truly provide information on the way acidity is dealt with in the plasma and this measurement should be interpreted with caution when assessing acid-base imbalance. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
- Subjects :
- HOMEOSTASIS
PH
030309 nutrition & dietetics
METABOLIC-ACIDOSIS
PROTEIN
030209 endocrinology & metabolism
Titratable acid
Acid–base homeostasis
Acid-Base Imbalance
Buffers
Critical Care and Intensive Care Medicine
Acid excretion
Excretion
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Medicine
Net acid production
LOAD
Food science
ComputingMilieux_MISCELLANEOUS
Acid-Base Equilibrium
2. Zero hunger
chemistry.chemical_classification
FOODS
EXCRETION
0303 health sciences
Nutrition and Dietetics
Acid-base balance
business.industry
HUMANS
Metabolism
Phosphate
Diet
Respiratory Transport
Amino acid
Kidney Tubules
Biochemistry
chemistry
Acid–base reaction
Net acid excretion
BONE
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Subjects
Details
- Language :
- English
- ISSN :
- 02615614
- Database :
- OpenAIRE
- Journal :
- Clinical Nutrition, Clinical Nutrition, Elsevier, 2012, 31 (3), pp.313-321. ⟨10.1016/j.clnu.2012.01.006⟩
- Accession number :
- edsair.doi.dedup.....a6e3094c5ee1f6b724180579206c6f2b