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Assessment of viable tissue in Q-wave regions by metabolic imaging using single-photon emission computed tomography in ischemic cardiomyopathy
- Source :
- American Journal of Cardiology, 89, 1171-1175. Elsevier Inc.
- Publication Year :
- 2002
-
Abstract
- Chronic electrocardiographic Q waves are often believed to reflect irreversibly scarred, transmurally infarcted myocardium. The aim of this study was to evaluate whether residual viable tissue persists in dysfunctional myocardial regions related to chronic Q waves on the surface electrocardiogram. A total of 148 patients with healed myocardial infarction and impaired left ventricular (LV) function with heart failure symptoms underwent electrocardiography and metabolic imaging using technetium (Tc-99m) tetrofosmin/F18-fluorodeoxyglucose (FDG) single-photon emission computed tomography (SPECT). The left ventricle was divided into 4 major regions to compare myocardial viability in regions with and without chronic Q waves on surface electrocardiography. According to FDG SPECT metabolic imaging, residual viable tissue persisted in a high proportion (61%) of dysfunctional myocardial regions with chronic Q waves. Regions with chronic Q waves were more often dysfunctional than regions without Q waves. Moreover, dysfunctional regions with chronic Q waves were less frequently viable compared with dysfunctional regions without Q waves on the electrocardiogram. This study demonstrates that chronic Q waves on electrocardiography do not necessarily imply irreversibly scarred myocardium. Residual viable tissue persists in a high proportion of dysfunctional ventricular regions according to FDG SPECT metabolic imaging.
- Subjects :
- Male
medicine.medical_specialty
Heart disease
Heart Ventricles
Myocardial Ischemia
Single-photon emission computed tomography
QT interval
Electrocardiography
Ventricular Dysfunction, Left
Fluorodeoxyglucose F18
Internal medicine
medicine
Humans
Aged
Tomography, Emission-Computed, Single-Photon
Ischemic cardiomyopathy
medicine.diagnostic_test
business.industry
Stroke Volume
Middle Aged
Image Enhancement
medicine.disease
medicine.anatomical_structure
Echocardiography
Ventricle
Heart failure
Cardiology
Female
Radiopharmaceuticals
Cardiomyopathies
Cardiology and Cardiovascular Medicine
business
Emission computed tomography
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- American Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....a6ee0b318b01b16a2ece3e4a7e1148f6