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Evaluation of osteopenia and osteoporosis in younger breast cancer survivors compared with cancer-free women: a prospective cohort study
- Source :
- Breast Cancer Research, Vol 20, Iss 1, Pp 1-10 (2018), Breast Cancer Research : BCR
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Osteoporosis, an indicator of significant bone loss, has been consistently reported among older breast cancer survivors. Data are limited on the incidence of osteopenia, an earlier indicator of bone loss, and osteoporosis in younger breast cancer survivors compared with cancer-free women. Methods We prospectively examined bone loss in 211 breast cancer survivors (mean age at breast cancer diagnosis = 47 years) compared with 567 cancer-free women in the same cohort with familial risk for breast cancer. Multivariable-adjusted Cox proportional hazards models were used to estimate HRs and 95% CIs of osteopenia and/or osteoporosis incidence based on physician diagnosis. Results During a mean follow-up of 5.8 years, 66% of breast cancer survivors and 53% of cancer-free women reported having a bone density examination, and 112 incident cases of osteopenia and/or osteoporosis were identified. Breast cancer survivors had a 68% higher risk of osteopenia and osteoporosis compared to cancer-free women (HR = 1.68, 95% CI = 1.12–2.50). The association was stronger among recent survivors after only 2 years of follow-up (HR = 2.74, 95% CI = 1.37–5.47). A higher risk of osteopenia and osteoporosis was also observed among survivors aged ≤ 50 years, estrogen receptor-positive tumors, and those treated with aromatase inhibitors alone or chemotherapy plus any hormone therapy relative to cancer-free women. Conclusions Younger breast cancer survivors are at higher risk for osteopenia and osteoporosis compared to cancer-free women. Studies are needed to determine effective approaches to minimize bone loss in this population.
- Subjects :
- Oncology
Adult
medicine.medical_specialty
Bone loss
Bone density
Antineoplastic Agents, Hormonal
medicine.medical_treatment
Osteoporosis
Population
030209 endocrinology & metabolism
Breast Neoplasms
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Breast cancer
Cancer Survivors
Bone Density
Internal medicine
Cancer-free women
medicine
Humans
Prospective Studies
education
Prospective cohort study
education.field_of_study
business.industry
Aromatase Inhibitors
Osteopenia
Incidence
Age Factors
Breast cancer survivors
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
3. Good health
Postmenopause
030220 oncology & carcinogenesis
Cohort
Female
Hormone therapy
business
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research
- Accession number :
- edsair.doi.dedup.....a6f6d147b53f031b89a51edc936a00b0