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A compact fiber-optic probe-based singlet oxygen luminescence detection system
- Source :
- Journal of Biophotonics
- Publication Year :
- 2016
-
Abstract
- This paper presents a novel compact fiberoptic based singlet oxygen near-infrared luminescence probe coupled to an InGaAs/InP single photon avalanche diode (SPAD) detector. Patterned time gating of the single-photon detector is used to limit unwanted dark counts and eliminate the strong photosensitizer luminescence background. Singlet oxygen luminescence detection at 1270 nm is confirmed through spectral filtering and lifetime fitting for Rose Bengal in water, and Photofrin in methanol as model photosensitizers. The overall performance, measured by the signal-to-noise ratio, improves by a factor of 50 over a previous system that used a fiberoptic-coupled superconducting nanowire single-photon detector. The effect of adding light scattering to the photosensitizer is also examined as a first step towards applications in tissue in vivo.
- Subjects :
- Optical fiber
Luminescence
Physics::Instrumentation and Detectors
General Physics and Astronomy
Physics::Optics
02 engineering and technology
Signal-To-Noise Ratio
01 natural sciences
General Biochemistry, Genetics and Molecular Biology
Light scattering
Article
law.invention
010309 optics
chemistry.chemical_compound
law
0103 physical sciences
Fiber Optic Technology
General Materials Science
Photosensitizer
Photosensitizing Agents
Singlet Oxygen
business.industry
Chemistry
Singlet oxygen
Detector
General Engineering
General Chemistry
021001 nanoscience & nanotechnology
Photon counting
QC0350
Single-photon avalanche diode
Optoelectronics
0210 nano-technology
business
Subjects
Details
- Language :
- English
- ISSN :
- 1864063X
- Database :
- OpenAIRE
- Journal :
- Journal of Biophotonics
- Accession number :
- edsair.doi.dedup.....a6fc389f38745860057057e8e5a9301f