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A multiparametric approach to discriminate the impacts of different degrees of invasiveness of surgical procedures in sheep

A multiparametric approach to discriminate the impacts of different degrees of invasiveness of surgical procedures in sheep

Authors :
Denys Durand
Alain Boissy
M. Faure
A. de Boyer des Roches
V. Paulmier
A. de la Foye
Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH)
VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)
Unité Mixte de Recherches sur les Herbivores ( UMR 1213 Herbivores )
VetAgro Sup ( VAS ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique ( INRA )
Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH)
VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)
Source :
Animal, Vol 11, Iss 12, Pp 2275-2284 (2017), 2017; 11. International European Congress of Behavioural Medicine and Animal Welfare, Samorin, SVK, 2017-09-14-2017-09-16, animal, animal, Cambridge University Press (CUP), 2017, pp.1-10. ⟨10.1017/S1751731117000805⟩, animal, Cambridge University Press (CUP), 2017, pp.1-10. 〈10.1017/S1751731117000805〉, 11. International European Congress of Behavioural Medicine and Animal Welfare, 11. International European Congress of Behavioural Medicine and Animal Welfare, Sep 2017, Samorin, Slovakia, Animal, Animal, Published by Elsevier (since 2021) / Cambridge University Press (until 2020), 2017, 11 (12), pp.1-10. ⟨10.1017/S1751731117000805⟩, animal, Published by Elsevier (since 2021) / Cambridge University Press (until 2020), 2017, 11 (12), pp.1-10. ⟨10.1017/S1751731117000805⟩
Publication Year :
2017
Publisher :
Elsevier, 2017.

Abstract

Epub 2017 May 04; Traumatic situations in animals induce responses including pain, expressed through behavioural and physiological pathways such as inflammation, oxidative stress, hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system. As some of these systems can also be activated during excitement and situations with a positive valence, their use as a means to assess pain response is difficult. We explored (i) how these five aforementioned pathways change in sheep exposed to various degrees of invasiveness of surgical procedures despite a therapeutic regimen and (ii) whether a multiparametric analysis that combines information from these five pathways enhances the discrimination between these situations, and estimates the relative importance of these pathways in the response. We used 24 adult sheep split into four treatments: Control (C; no fasting, no anaesthesia, no surgery), Sham (S; fasting, anaesthesia, no surgery), Rumen Canulation (R; fasting, anaesthesia, rumen cannulation) and Rumen-Duodenal-Ileum cannulation (RDI; fasting, anaesthesia, cannulation of the rumen, duodenum and ileum). Sheep' responses were measured for 5 days after surgery. When considering each behavioural or physiological pathway independently, discrimination between treatments was acceptable, its sensitivity (Se) ranging from 0% to 100%, and its specificity (Sp) ranging from 62% to 100%. The multiparametric analysis gathering information from the five pathways enhanced the effectiveness of discrimination between treatments (Se, 50% to 100%; Sp, 82% to 100%), and gave additional information on the relative contribution of each pathway to the global sheep response. Sheep global response was higher when exposed to a surgery, and increased with the surgery invasiveness. This response relied mostly on inflammation (absolute correlation for haptoglobin, 0.89), HPA (cortisol, 0.85) and behaviour (antalgic postures, 0.85). The multiparametric approach seems to be a promising tool to discriminate between different degrees of invasiveness of surgical procedures.

Details

Language :
English
ISSN :
17517311 and 1751732X
Volume :
11
Issue :
12
Database :
OpenAIRE
Journal :
Animal
Accession number :
edsair.doi.dedup.....a701ea153a9cde37ad50baa631017b7e
Full Text :
https://doi.org/10.1017/S1751731117000805⟩