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A multiparametric approach to discriminate the impacts of different degrees of invasiveness of surgical procedures in sheep
A multiparametric approach to discriminate the impacts of different degrees of invasiveness of surgical procedures in sheep
- Source :
- Animal, Vol 11, Iss 12, Pp 2275-2284 (2017), 2017; 11. International European Congress of Behavioural Medicine and Animal Welfare, Samorin, SVK, 2017-09-14-2017-09-16, animal, animal, Cambridge University Press (CUP), 2017, pp.1-10. ⟨10.1017/S1751731117000805⟩, animal, Cambridge University Press (CUP), 2017, pp.1-10. 〈10.1017/S1751731117000805〉, 11. International European Congress of Behavioural Medicine and Animal Welfare, 11. International European Congress of Behavioural Medicine and Animal Welfare, Sep 2017, Samorin, Slovakia, Animal, Animal, Published by Elsevier (since 2021) / Cambridge University Press (until 2020), 2017, 11 (12), pp.1-10. ⟨10.1017/S1751731117000805⟩, animal, Published by Elsevier (since 2021) / Cambridge University Press (until 2020), 2017, 11 (12), pp.1-10. ⟨10.1017/S1751731117000805⟩
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Epub 2017 May 04; Traumatic situations in animals induce responses including pain, expressed through behavioural and physiological pathways such as inflammation, oxidative stress, hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system. As some of these systems can also be activated during excitement and situations with a positive valence, their use as a means to assess pain response is difficult. We explored (i) how these five aforementioned pathways change in sheep exposed to various degrees of invasiveness of surgical procedures despite a therapeutic regimen and (ii) whether a multiparametric analysis that combines information from these five pathways enhances the discrimination between these situations, and estimates the relative importance of these pathways in the response. We used 24 adult sheep split into four treatments: Control (C; no fasting, no anaesthesia, no surgery), Sham (S; fasting, anaesthesia, no surgery), Rumen Canulation (R; fasting, anaesthesia, rumen cannulation) and Rumen-Duodenal-Ileum cannulation (RDI; fasting, anaesthesia, cannulation of the rumen, duodenum and ileum). Sheep' responses were measured for 5 days after surgery. When considering each behavioural or physiological pathway independently, discrimination between treatments was acceptable, its sensitivity (Se) ranging from 0% to 100%, and its specificity (Sp) ranging from 62% to 100%. The multiparametric analysis gathering information from the five pathways enhanced the effectiveness of discrimination between treatments (Se, 50% to 100%; Sp, 82% to 100%), and gave additional information on the relative contribution of each pathway to the global sheep response. Sheep global response was higher when exposed to a surgery, and increased with the surgery invasiveness. This response relied mostly on inflammation (absolute correlation for haptoglobin, 0.89), HPA (cortisol, 0.85) and behaviour (antalgic postures, 0.85). The multiparametric approach seems to be a promising tool to discriminate between different degrees of invasiveness of surgical procedures.
- Subjects :
- Male
Hydrocortisone
[SDV]Life Sciences [q-bio]
Pituitary-Adrenal System
ruminant
[SHS]Humanities and Social Sciences
0403 veterinary science
surgery
Random Allocation
stress
ovin
pain
ComputingMilieux_MISCELLANEOUS
biology
Behavior, Animal
Haptoglobin
04 agricultural and veterinary sciences
Animal culture
medicine.anatomical_structure
Anesthesia
medicine.symptom
medicine.drug
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Rumen
mouton
040301 veterinary sciences
Duodenum
Ileum
Inflammation
Autonomic Nervous System
SF1-1100
Catheterization
multiparametric approach
medicine
Animals
[INFO]Computer Science [cs]
Sheep
[ SDV ] Life Sciences [q-bio]
Multiparametric Analysis
0402 animal and dairy science
stress oxydatif
Surgical procedures
040201 dairy & animal science
Surgery
Autonomic nervous system
intervention chirurgicale
biology.protein
Animal Science and Zoology
Subjects
Details
- Language :
- English
- ISSN :
- 17517311 and 1751732X
- Volume :
- 11
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Animal
- Accession number :
- edsair.doi.dedup.....a701ea153a9cde37ad50baa631017b7e
- Full Text :
- https://doi.org/10.1017/S1751731117000805⟩