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Vaccines: SARS‐CoV‐2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination (Adv. Mater. 50/2020)

Authors :
Wei‐Chiao Huang
Shiqi Zhou
Xuedan He
Kevin Chiem
Moustafa T. Mabrouk
Ruth H. Nissly
Ian M. Bird
Mike Strauss
Suryaprakash Sambhara
Joaquin Ortega
Elizabeth A. Wohlfert
Luis Martinez‐Sobrido
Suresh V. Kuchipudi
Bruce A. Davidson
Jonathan F. Lovell
Source :
Advanced Materials
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

In article number 2005637, Jonathan F Lovell and co-workers show that the SARS-CoV-2 RBD surface protein becomes a potent immunogen when presented in nanoparticle format Using a vaccine adjuvant that spontaneously converts soluble recombinant antigens into stable particles, immunization studies in mice and rabbits shows that the particle-based RBD elicits strong immune responses and potent antibodies capable of neutralizing the virus

Details

ISSN :
15214095 and 09359648
Volume :
32
Database :
OpenAIRE
Journal :
Advanced Materials
Accession number :
edsair.doi.dedup.....a728ce45e18db8391ddac7e7f0a5aa2f
Full Text :
https://doi.org/10.1002/adma.202070373