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Development of a Rat Clinical Frailty Index
- Source :
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publication Year :
- 2016
-
Abstract
- Rats are a commonly used model for aging studies, and a frailty assessment tool for rats would be of considerable value. There has been a recent focus on the development of preclinical models of frailty in mice. A mouse clinical frailty index (FI) was developed based on clinical frailty assessment tools. This FI measures the accumulation of clinically evident health-related deficits in mice. This paper aimed to develop a rat clinical FI. Male Fischer 344 rats were aged from 6 to 9 months (n = 12), and from 13 to 21 months (n = 41). A FI comprised of 27 health-related deficits was developed from a review of the literature and consultation with a veterinarian. Deficits were scored 0 if absent, 0.5 if mild, or 1 if severe. A FI score was determined for each rat every 3–4 months, and for the older group mortality was assessed up to 21 months. Mean FI scores significantly increased at each time point for the older rats. A high FI score measured at both 17 months of age and terminally was also associated with decreased probability of survival as assessed with Kaplan–Meier curves. The rat clinical FI has significant value for use in aging and interventional studies.
- Subjects :
- 0301 basic medicine
Research design
medicine.medical_specialty
Aging
Deficit accumulation
Frail Elderly
Frailty Index
Preclinical models
Motor Activity
03 medical and health sciences
Internal medicine
Physical Conditioning, Animal
medicine
Animals
Health Status Indicators
Humans
Frail elderly
Motor activity
Geriatric Assessment
Aged
Frailty index
business.industry
Geriatric assessment
Frailty assessment
Rats
030104 developmental biology
Research Design
Models, Animal
Original Article
Geriatrics and Gerontology
business
Probability of survival
Subjects
Details
- ISSN :
- 1758535X
- Volume :
- 72
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Accession number :
- edsair.doi.dedup.....a747bd089efab887fd585e3e3ee03326