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Adapting social neuroscience measures for schizophrenia clinical trials, part 3: Fathoming external validity
- Source :
- Olbert, CM; Penn, DL; Kern, RS; Lee, J; Horan, WP; Reise, SP; et al.(2013). Adapting social neuroscience measures for schizophrenia clinical trials, part 3: Fathoming external validity. Schizophrenia Bulletin, 39(6), 1211-1218. doi: 10.1093/schbul/sbt130. UCLA: Retrieved from: http://www.escholarship.org/uc/item/93b7q9jp, Schizophrenia bulletin, vol 39, iss 6
- Publication Year :
- 2013
- Publisher :
- eScholarship, University of California, 2013.
-
Abstract
- It is unknown whether measures adapted from social neuroscience linked to specific neural systems will demonstrate relationships to external variables. Four paradigms adapted from social neuroscience were administered to 173 clinically stable outpatients with schizophrenia to determine their relationships to functionally meaningful variables and to investigate their incremental validity beyond standard measures of social and nonsocial cognition. The 4 paradigms included 2 that assess perception of nonverbal social and action cues (basic biological motion and emotion in biological motion) and 2 that involve higher level inferences about self and others' mental states (self-referential memory and empathic accuracy). Overall, social neuroscience paradigms showed significant relationships to functional capacity but weak relationships to community functioning; the paradigms also showed weak correlations to clinical symptoms. Evidence for incremental validity beyond standard measures of social and nonsocial cognition was mixed with additional predictive power shown for functional capacity but not community functioning. Of the newly adapted paradigms, the empathic accuracy task had the broadest external validity. These results underscore the difficulty of translating developments from neuroscience into clinically useful tasks with functional significance. © 2013 The Author 2013.
- Subjects :
- Psychiatry
Adult
Male
Clinical Trials as Topic
Psychology and Cognitive Sciences
Luria-Nebraska Neuropsychological Battery
Neurosciences
social neuroscience
Reproducibility of Results
Social Behavior Disorders
social cognition
Middle Aged
Basic Behavioral and Social Science
Medical and Health Sciences
Brain Disorders
functional outcome
schizophrenia
Mental Health
Good Health and Well Being
Clinical Research
Behavioral and Social Science
Humans
Female
Cognition Disorders
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Olbert, CM; Penn, DL; Kern, RS; Lee, J; Horan, WP; Reise, SP; et al.(2013). Adapting social neuroscience measures for schizophrenia clinical trials, part 3: Fathoming external validity. Schizophrenia Bulletin, 39(6), 1211-1218. doi: 10.1093/schbul/sbt130. UCLA: Retrieved from: http://www.escholarship.org/uc/item/93b7q9jp, Schizophrenia bulletin, vol 39, iss 6
- Accession number :
- edsair.doi.dedup.....a74d83c53f9235d2a979210484a8f131