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Long non-coding RNA SOX21-AS1 sponges miR-145 to promote the tumorigenesis of colorectal cancer by targeting MYO6
- Source :
- Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 96
- Publication Year :
- 2017
-
Abstract
- Emerging evidences have proved that long non-coding RNAs (lncRNAs) act as important molecular regulator in the tumor progression, including colorectal cancer (CRC). LncRNA SOX21-AS1 has been verified as oncogenic molecular in other cancers and tumorigenesis. In present study, our team investigates the clinical characteristic and molecular function in CRC carcinogenesis. Results showed that lncRNA SOX21-AS1 expression was significantly over-expressed in CRC tissue samples and cells. The aberrant over-expression of SOX21-AS1 indicated poor prognosis of CRC patients. In vitro and in vivo validation experiments, SOX21-AS1 silencing inhibited the proliferation, invasion, and decreased the tumor growth of CRC cells. Moreover, miR-145 was proved to be the target of SOX21-AS1, besides, myosin VI (MYO6) was found to be one of the targets of miR-145 using bioinformatics prediction programs and rescue confirmation experiments. In summary, our study reveals the tumorigenic effect of lncRNA SOX21-AS1 in CRC cells via targeting miR-145/MYO6, providing a novel insight for CRC carcinogenesis.
- Subjects :
- 0301 basic medicine
Male
Colorectal cancer
Carcinogenesis
Regulator
Biology
medicine.disease_cause
Cell Line
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line, Tumor
microRNA
medicine
Gene silencing
Humans
Cell Proliferation
Pharmacology
Myosin Heavy Chains
HEK 293 cells
General Medicine
Middle Aged
medicine.disease
HCT116 Cells
Prognosis
digestive system diseases
Long non-coding RNA
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
HEK293 Cells
Tumor progression
030220 oncology & carcinogenesis
SOXB2 Transcription Factors
Cancer research
Female
RNA, Long Noncoding
Colorectal Neoplasms
HT29 Cells
Subjects
Details
- ISSN :
- 19506007
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Biomedicinepharmacotherapy = Biomedecinepharmacotherapie
- Accession number :
- edsair.doi.dedup.....a750b3d5a3d9cf5e887bf3aabb4da318