Back to Search
Start Over
Xenon-related Analgesia
- Source :
- The Clinical Journal of Pain. 29:639-643
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- The noble gas xenon has been known for >50 years in the field of anesthesia with an emerging series of favorable features; several clinical and preclinical studies performed over the last years reveal a renewed interest because they substantially agree on attributing relevant analgesic properties to xenon. The main mechanism of action is the inhibition of N-methyl-D-aspartate receptors of glutamate; it involves the blocking of painful stimuli transmissions from peripheral tissues to the brain and it also avoids the development of pain hypersensitivity. Therefore, this mechanism is responsible for the inhibition of pain transmission at spinal and supraspinal levels, as well as the cortical level. In all these levels of pain pathways, as the development of hyperalgesia is possible, xenon efficacy can also be based on the blocking of these processes. Several forms of pain share such mechanisms in their maintenance, and xenon can be successfully used at low dosages, which have no effects on vital parameters. The literature shows that analgesic features could also emerge outside the field of anesthesia; thus, this could permit xenon to have a larger usage according to local availability.
- Subjects :
- Xenon
business.industry
Mechanism (biology)
Analgesic
Glutamate receptor
Brain
Pain
chemistry.chemical_element
Pain hypersensitivity
Peripheral
Anesthesiology and Pain Medicine
chemistry
Anesthetics, Inhalation
Hyperalgesia
Animals
Humans
Pain Management
Medicine
Neurology (clinical)
Analgesia
medicine.symptom
business
Neuroscience
Pain transmission
Subjects
Details
- ISSN :
- 07498047
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- The Clinical Journal of Pain
- Accession number :
- edsair.doi.dedup.....a7552e42ab6e8d071ed848264c8723bb
- Full Text :
- https://doi.org/10.1097/ajp.0b013e31826b12f5