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Pesticide Use and Incident Hypothyroidism in Pesticide Applicators in the Agricultural Health Study
- Source :
- Environmental Health Perspectives
- Publication Year :
- 2018
- Publisher :
- Environmental Health Perspectives, 2018.
-
Abstract
- Though evidence suggests that some pesticides may have thyroid-disrupting properties, prospective studies of associations between specific pesticides and incident thyroid disease are limited.We evaluated associations between use of specific pesticides and incident hypothyroidism in private pesticide applicators in the Agricultural Health Study (AHS).Self-reported incident hypothyroidism ([Formula: see text] cases) was studied in relation to ever-use and intensity-weighted cumulative days of pesticide use at study enrollment. We estimated adjusted hazard ratios (HRs) and 95% confidence intervals (CI) using Cox proportional hazards models applied to 35,150 male and female applicators followed over 20 y. All models were stratified by state and education to meet proportional hazards assumptions ([Formula: see text] for age x covariate interactions). Models of pesticides that did not meet proportional hazards assumptions were stratified by median attained age (62 y).Hypothyroidism risk was significantly increased with ever- vs. never-use of four organochlorine insecticides (aldrin, heptachlor, and lindane among participants with attained age [Formula: see text]; chlordane in all participants), four organophosphate insecticides (coumaphos in those [Formula: see text]; diazinon, dichlorvos, and malathion in all participants) and three herbicides (dicamba, glyphosate, and 2,4-D in all participants). HRs ranged from 1.21; 95% CI: 1.04, 1.41 (chlordane) to 1.54; 95% CI: 1.23, 19.4 (lindane in those [Formula: see text]). Hypothyroidism risk was greatest among those with higher intensity-weighted lifetime days of using chlordane, lindane, coumaphos (over age 62), diazinon, permethrin, and 2,4-D.Our findings support associations between exposure to several pesticides and increased hypothyroidism risk. These findings are generally consistent with prior analyses of prevalent hypothyroidism in the AHS. https://doi.org/10.1289/EHP3194.
- Subjects :
- Adult
Male
endocrine system
endocrine system diseases
Health, Toxicology and Mutagenesis
MEDLINE
010501 environmental sciences
01 natural sciences
Young Adult
03 medical and health sciences
0302 clinical medicine
Pesticide use
Hypothyroidism
Occupational Exposure
Environmental health
North Carolina
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Pesticides
Prospective cohort study
Aged
0105 earth and related environmental sciences
2. Zero hunger
business.industry
Incidence
Research
Thyroid disease
Incidence (epidemiology)
Public Health, Environmental and Occupational Health
Environmental Exposure
Middle Aged
Pesticide
medicine.disease
Iowa
Agricultural Workers' Diseases
Agriculture
business
Subjects
Details
- ISSN :
- 15529924 and 00916765
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Environmental Health Perspectives
- Accession number :
- edsair.doi.dedup.....a758b08f0ff05b54e8ad28d10066b9ae