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Volatile organic compounds in uremia
- Source :
- PLoS ONE, PLoS ONE, Vol 7, Iss 9, p e46258 (2012)
- Publication Year :
- 2012
-
Abstract
- BackgroundAlthough "uremic fetor" has long been felt to be diagnostic of renal failure, the compounds exhaled in uremia remain largely unknown so far. The present work investigates whether breath analysis by ion mobility spectrometry can be used for the identification of volatile organic compounds retained in uremia.MethodsBreath analysis was performed in 28 adults with an eGFR ≥ 60 ml/min per 1.73 m(2), 26 adults with chronic renal failure corresponding to an eGFR of 10-59 ml/min per 1.73 m(2), and 28 adults with end-stage renal disease (ESRD) before and after a hemodialysis session. Breath analysis was performed by ion mobility spectrometryafter gas-chromatographic preseparation. Identification of the compounds of interest was performed by thermal desorption gas chromatography/mass spectrometry.ResultsBreath analyses revealed significant differences in the spectra of patients with and without renal failure. Thirteen compounds were chosen for further evaluation. Some compounds including hydroxyacetone, 3-hydroxy-2-butanone and ammonia accumulated with decreasing renal function and were eliminated by dialysis. The concentrations of these compounds allowed a significant differentiation between healthy, chronic renal failure with an eGFR of 10-59 ml/min, and ESRD (pConclusionImpairment of renal function induces a characteristic fingerprint of volatile compounds in the breath. The technique of ion mobility spectrometry can be used for the identification of lipophilic uremic retention molecules.
- Subjects :
- Male
Anatomy and Physiology
Critical Care and Emergency Medicine
Pulmonology
medicine.medical_treatment
urologic and male genital diseases
Gastroenterology
Engineering
Chronic Kidney Disease
Multidisciplinary
Chemistry
Middle Aged
Clinical Laboratory Sciences
Breath Tests
Nephrology
Medicine
Female
Hemodialysis
medicine.symptom
Research Article
Test Evaluation
Adult
medicine.medical_specialty
Drugs and Devices
Ion-mobility spectrometry
Science
Renal function
Bioengineering
Gas Chromatography-Mass Spectrometry
Medical Devices
Renal Dialysis
Diagnostic Medicine
Internal medicine
medicine
Humans
Biology
Dialysis
Uremia
Volatile Organic Compounds
Uremic fetor
Renal System
medicine.disease
Endocrinology
Breath gas analysis
Kidney Failure, Chronic
Acute Renal Failure
Gas chromatography–mass spectrometry
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....a75adf292306a1fd07873b5748cf1c7a