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C-type lectins facilitate tumor metastasis
- Source :
- Oncology Letters
- Publication Year :
- 2016
- Publisher :
- Spandidos Publications, 2016.
-
Abstract
- Metastasis, a life-threatening complication of cancer, leads to the majority of cases of cancer-associated mortality. Unfortunately, the underlying molecular and cellular mechanisms of cancer metastasis remain to be fully elucidated. C-type lectins are a large group of proteins, which share structurally homologous carbohydrate-recognition domains (CRDs) and possess diverse physiological functions, including inflammation and antimicrobial immunity. Accumulating evidence has demonstrated the contribution of C-type lectins in different steps of the metastatic spread of cancer. Notably, a substantial proportion of C-type lectins, including selectins, mannose receptor (MR) and liver and lymph node sinusoidal endothelial cell C-type lectin, are important molecular targets for the formation of metastases in vitro and in vivo. The present review summarizes what has been found regarding C-type lectins in the lymphatic and hematogenous metastasis of cancer. An improved understanding the role of C-type lectins in cancer metastasis provides a comprehensive perspective for further clarifying the molecular mechanisms of cancer metastasis and supports the development of novel C-type lectins-based therapies the for prevention of metastasis in certain types of cancer.
- Subjects :
- 0301 basic medicine
tumor
Cancer Research
Review
Metastasis
03 medical and health sciences
0302 clinical medicine
medicine
metastasis
C-type lectins
Lymph node
biology
Oncogene
Lectin
Cancer
medicine.disease
Molecular medicine
030104 developmental biology
Lymphatic system
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
biology.protein
Cancer research
lectin
Selectin
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....a7623321d2d4281adb52ea8b611b7960