Nitric oxide products are not associated with metabolic syndrome

Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS.A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria.Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 μmol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted RUnlike XOD, MDA and AOPP, NOx is not associated with MetS.Azot-monoksid (NO) je biomarker oksidativnog stresa i smatra se jednom od ključnih determinanti energetskog metabolizma i vaskularnog tonusa. S obzirom na oprečne rezultate dosadašnjih studija koje se odnose na povezanost između produkata azot-monoksida (NOx) i metaboličkog sindroma (MetS), cilj ove studije je da se ispita njihova potencijalna povezanost. Takođe, cilj je i da se ispita povezanost između širokog spektra ostalih biomarkera oksidativnog stresa [npr., malondialdehida (MDA), produkata uznapredovale oksidacije proteina (AOPP), ksantin oksidoreduktaze (XOD), ksantin oksidaze (XO) i ksantin dehidrogenaze (XDH)] i MetS.Ukupno 109 dobrovoljaca (od kojih je 46,8% ispunjavalo kriterijume za MetS) je uključeno u studiju preseka. Mereni su biohemijski i antropometrijski parametri, kao i krvni pritisak. Dijagnoza MetS-a je postavljena prema kriterijumima Međunarodnog udruženja za dijabetes.Multivarijantna logistička regresija je pokazala da su XOD (OR=1,011; 95% CI 1,002–1,019; p=0,016), XO (OR=1,014; 95% CI 1,003–1,026; p=0,016), MDA (OR=1,113; 95% CI 1,038–1,192; p=0,003) i AOPP (OR=1,022; 95% CI 1,005–1,039; p=0,012) nezavisni prediktori MetS-a, ali postojanje povezanosti između NOx i MetS nije utvrđeno. Sa porastom XOD za 1 U/L, XO za 1 U/L, MDA za 1 μmol/L i AOPP za 1 T/L verovatnoćapojave MetS-a je rasla za 1,1%, 1,4%, 11,3% i 2,2%. Prilagođeni RZa razliku od XOD, MDA i AOPP, NOx nisu povezani sa MetS-om.