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The serum hepcidin:ferritin ratio is a potential biomarker for cirrhosis
- Source :
- Liver international : official journal of the International Association for the Study of the Liver. 32(9)
- Publication Year :
- 2012
-
Abstract
- Background Serum hepcidin concentration is potentially affected by inflammation and iron stores in chronic liver disease (CLD), but little is known about the relationship between hepcidin and the degree of hepatic fibrosis. We investigated the potential role of serum hepcidin as a biomarker of advanced liver disease. Methods Serum hepcidin was measured in 332 adults with CLD of varying aetiologies, 45 healthy and 50 non-liver disease patient controls. Liver biopsy data were available for 228 CLD subjects. Results Hepcidin was decreased in CLD patients compared with non-liver disease patient controls (P similar to
- Subjects :
- Adult
Liver Cirrhosis
Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Cirrhosis
Gene Expression
Chronic liver disease
Liver disease
Hemoglobins
Hepcidins
Liver Function Tests
Hepcidin
Predictive Value of Tests
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Serum Albumin
Hepatology
medicine.diagnostic_test
biology
business.industry
Transferrin saturation
nutritional and metabolic diseases
Alanine Transaminase
Bilirubin
Middle Aged
medicine.disease
Ferritin
Endocrinology
Liver
ROC Curve
Liver biopsy
Chronic Disease
Ferritins
biology.protein
Disease Progression
Transferrins
Female
business
Liver function tests
Biomarkers
Liver Failure
Antimicrobial Cationic Peptides
Subjects
Details
- ISSN :
- 14783231
- Volume :
- 32
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Liver international : official journal of the International Association for the Study of the Liver
- Accession number :
- edsair.doi.dedup.....a777fb26c428319c6aeff53a6d7a69f9