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Examining variation and temporal dynamics of extracellular matrix biomarkers following acute myocardial infarction

Authors :
Morgane M Brunton-O'Sullivan
Ana S Holley
Georgina K Bird
Gisela A Kristono
Scott A Harding
Peter D Larsen
Source :
Biomarkers in Medicine. 16:147-161
Publication Year :
2022
Publisher :
Future Medicine Ltd, 2022.

Abstract

Plain language summary The cardiac extracellular matrix (ECM) maintains the structural integrity of the heart, and can be measured in human circulation using ECM biomarkers. Understanding the levels of variation and temporal dynamics that exist in ECM biomarkers following a heart attack is important for establishing an optimal biomarker panel that may be useful in heart research. A single blood sample was collected from 12 healthy volunteers. Multiple bloods samples were collected from 23 heart attack patients during hospital admission (day 1–3) and 6 months post heart attack. About 12 ECM biomarkers were measured from these blood samples. When compared with healthy levels, seven ECM biomarkers were significantly altered in heart attack patients, and six of these biomarkers displayed stable expression during hospital admission. Variability existed within biomarker levels and this was not well described by traditional heart attack risk factors, such as age or heart attack size. Thus, the source of biomarker variability remains unknown in this study. Overall, we suggest these seven ECM biomarkers may be of interest for future studies in the setting of heart attack research.

Details

ISSN :
17520371 and 17520363
Volume :
16
Database :
OpenAIRE
Journal :
Biomarkers in Medicine
Accession number :
edsair.doi.dedup.....a7819b307a7d64451504dcbc35b31f69
Full Text :
https://doi.org/10.2217/bmm-2021-0531