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Effects of chicken intestinal antimicrobial peptides on humoral immunity of chickens and antibody titres after vaccination with infectious bursal disease virus vaccine in chicken
- Source :
- Archives of animal nutrition. 60(5)
- Publication Year :
- 2006
-
Abstract
- Sixty chickens were randomly divided into two groups (30 chickens in each group) to determine the effect of oral administration of chicken intestinal antimicrobial peptides (CIAMP) on the humoral immune response. Chickens of both groups were fed the same diet. In the treatment group chickens received drinking water supplemented with CIAMP (1 microg/ml) right after hatching. Samples of blood, bursa of Fabricus, spleen and intestine were taken at day 1, 4, 7, 10 and 17 of experiment. CIAMP supplementation enhanced the content of IgG and IgM in serum from day 4-10 and day 10-17, respectively, (p < 0.05), IgM-forming cells in bursa of Fabricus and spleen at the age of 7 days (p < 0.05) and IgG-forming cells in bursa of Fabricus at the age of 4 days (p < 0.05). In addition, CIAMP enhanced the IgA-forming cells in caecal tonsils diffuse area at day 4 (p < 0.05). Furthermore, CIAMP enhanced the antibody response to infectious bursal disease virus vaccine (IBDV) in chickens 21 days following IBDV vaccine administration (p < 0.05). These results suggested that CIAMP could modulate the humoral immune response of chickens and increased the antibody titres of infectious bursal disease virus vaccine.
- Subjects :
- animal structures
Antimicrobial peptides
Spleen
Antibodies, Viral
Infectious bursal disease virus
Infectious bursal disease
Defensins
Random Allocation
Immune system
Anti-Infective Agents
Oral administration
medicine
Animals
General Veterinary
biology
General Medicine
medicine.disease
Virology
Vaccination
medicine.anatomical_structure
Immunoglobulin M
Immunoglobulin G
embryonic structures
Immunology
Humoral immunity
Antibody Formation
biology.protein
Animal Science and Zoology
Antibody
Chickens
Antimicrobial Cationic Peptides
Subjects
Details
- ISSN :
- 1745039X
- Volume :
- 60
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Archives of animal nutrition
- Accession number :
- edsair.doi.dedup.....a788a58692f85f98ffc19da130712e09