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Function of abnormal corpora lutea in vivo after GnRH-induced ovulation in the anoestrous ewe
- Source :
- Reproduction. 84:131-137
- Publication Year :
- 1988
- Publisher :
- Bioscientifica, 1988.
-
Abstract
- Anoestrous Romney Marsh ewes with and without progesterone treatment (+P, -P) were treated with small-dose (250 ng) multiple injections of GnRH at 2-h intervals for 48 h. Animals were slaughtered on Days 4, 5, 7 and 11 after the end of GnRH treatment and luteal function was assessed by the measurement of daily plasma progesterone concentrations. In all animals which ovulated (29/32, 91%) peripheral progesterone concentrations rose to 0.5-1.0 ng/ml within 3 days of the end of GnRH treatment. In 7/7 (100%) +P animals and 5/22 (23%) -P animals, progesterone concentrations continued to rise and were maintained at levels greater than 1.5 ng/ml until slaughter. In the remaining -P animals, plasma progesterone concentrations declined to reach basal levels by Day 5. Corpora lutea recovered from these animals showed signs of premature regression on Day 5 and were fully regressed by Day 7. Progesterone priming delayed the occurrence of the LH surge which occurred 39.1 +/- 3.6 h after the end of GnRH treatment in the +P animals compared to 20.2 +/- 1.74 h (P less than 0.001) in the -P animals in which luteal function was abnormal and 22.4 +/- 4.35 h in the -P animals in which luteal function was normal. These results show that abnormal luteal function occurs in the majority of GnRH-treated ewes in the absence of progesterone pretreatment.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- endocrine system
Embryology
medicine.medical_specialty
medicine.medical_treatment
Luteolysis
Biology
Luteal phase
Anestrus
Basal (phylogenetics)
Endocrinology
Estrus
Ovulation Induction
Corpus Luteum
Induced ovulation
Internal medicine
medicine
Animals
Progesterone
Estrous cycle
Sheep
Obstetrics and Gynecology
Cell Biology
Luteinizing Hormone
medicine.anatomical_structure
Reproductive Medicine
Female
Ovulation induction
Luteinizing hormone
Pituitary Hormone-Releasing Hormones
Corpus luteum
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 17417899 and 14701626
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Reproduction
- Accession number :
- edsair.doi.dedup.....a79066808cd95ceb6b2925a8d7205559