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The effect of combination treatment using palonosetron and dexamethasone for the prevention of postoperative nausea and vomiting versus dexamethasone alone in women receiving intravenous patient-controlled analgesia
- Source :
- Korean Journal of Anesthesiology, Korean Journal of Anesthesiology, Vol 68, Iss 3, Pp 267-273 (2015)
- Publication Year :
- 2015
- Publisher :
- The Korean Society of Anesthesiologists, 2015.
-
Abstract
- Background The purpose of this study was to evaluate the effect of palonosetron combined with dexamethasone for the prevention of PONV compared to dexamethasone alone in women who received intravenous patient-controlled analgesia (IV-PCA) using fentanyl. Methods In this randomized, double-blinded, placebo-controlled study, 204 healthy female patients who were scheduled to undergo elective surgery under general anesthesia followed by IV-PCA for postoperative pain control were enrolled. Patients were divided into two groups: the PD group (palonosetron 0.075 mg and dexamethasone 5 mg IV; n = 102) and the D group (dexamethasone 5 mg IV; n = 102). The treatments were given after the induction of anesthesia. The incidence of nausea, vomiting, severity of nausea, and the use of rescue anti-emetics during the first 48 hours after surgery were evaluated. Results The incidence of PONV was significantly lower in the PD group compared with the D group during the 0-24 hours (43 vs. 59%) and 0-48 hours after surgery (45 vs. 63%) (P < 0.05). The severity of nausea during the 6-24 hours after surgery was significantly less in the PD group compared with the D group (P < 0.05). The incidence of rescue antiemetic used was significantly lower in the PD group than in the D group during the 0-6 hours after surgery (13.1 vs. 24.5%) (P < 0.05). Conclusions Palonosetron combined with dexamethasone was more effective in preventing PONV compared to dexamethasone alone in women receiving IV-PCA using fentanyl.
- Subjects :
- Postoperative nausea and vomiting
medicine.medical_specialty
Clinical Research Article
business.industry
Palonosetron
Dexamethasone
Fentanyl
Surgery
lcsh:RD78.3-87.3
Anesthesiology and Pain Medicine
Combined treatment
lcsh:Anesthesiology
Anesthesia
medicine
medicine.symptom
business
medicine.drug
Intravenous Patient-Controlled Analgesia
Subjects
Details
- Language :
- English
- ISSN :
- 20057563 and 20056419
- Volume :
- 68
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Korean Journal of Anesthesiology
- Accession number :
- edsair.doi.dedup.....a7a670970b601f2e63d9c82cf13e9d37