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Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells
- Source :
- Cell biology international. 25(6)
- Publication Year :
- 2001
-
Abstract
- A 17 kD heparin-binding protein (HBp17) has a biphasic dose-dependent effect on DNA synthesis in 3T3 cells. Maximal stimulation of DNA synthesis occurs at 8 ng/ml HBp17, but a half-maximal inhibition occurs at approximately 500 ng/ml. This inhibition can easily be reversed by addition of 400 pg/ml aFGF or 100 pg/ml bFGF, whereas EGF had no effect. This biphasic action of HBp17 was also seen in human umbilical vein endothelial cells (HUVEC), whereas it was not found in the malignant cell line, A431-AJC. The functional relationship between HBp17 and FGF is discussed.
- Subjects :
- DNA Replication
Umbilical Veins
Skin Neoplasms
Stimulation
Biology
Fibroblast growth factor
Umbilical vein
3T3 cells
Mice
medicine
Tumor Cells, Cultured
Animals
Humans
DNA synthesis
Epidermal Growth Factor
Fibroblast growth factor receptor 2
Intracellular Signaling Peptides and Proteins
Cell Biology
General Medicine
Fibroblast growth factor receptor 4
3T3 Cells
Molecular biology
medicine.anatomical_structure
Cell culture
Fibroblast Growth Factor 1
Intercellular Signaling Peptides and Proteins
Fibroblast Growth Factor 2
Endothelium, Vascular
Carrier Proteins
Cell Division
Subjects
Details
- ISSN :
- 10656995
- Volume :
- 25
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cell biology international
- Accession number :
- edsair.doi.dedup.....a7a9ff5abcca71cca37e6b0a5a6e4e3f