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Prevalence of pulmonary mycoses in smear-negative patients with suspected tuberculosis in the Brazilian Amazon

Authors :
Joycenea da Silva Matsuda
Silviane Bezerra Pinheiro
Antônio Alcirley da Silva Balieiro
Flor Ernestina Martinez-Espinosa
Carla Silvana da Silva Santos
João Vicente Braga de Souza
Daiana Rodrigues Torres
Hagen Frickmann
Bodo Wanke
Regia Cristina dos Santos Cavalcante
Mauro de Medeiros Muniz
Source :
Revista Iberoamericana de Micología. 38:111-118
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Background Pulmonary mycoses resemble clinically and radiologically chronic pulmonary tuberculosis. Studies describing the prevalence, etiology and clinical features of pulmonary mycosis are of crucial importance in the Brazilian Amazon. Aims To estimate the frequency of pulmonary mycoses in smear-negative tuberculosis patients; to describe their demographic, epidemiological, and clinical characteristics; and to evaluate diagnostic methods. Methods A cross-sectional study was conducted at two tuberculosis reference institutions in Amazonas, Brazil. We included 213 patients and collected clinical data, blood and induced sputum to perform serological, direct microscopy, microbiologic culture and PCR-based assays to identify infections caused by Aspergillus fumigatus, Paracoccidioides brasiliensis, Histoplasma capsulatum, Cryptococcus, and HIV. Chest computed tomography was also performed. Results Pulmonary mycoses were diagnosed in 7% (15/213) of the cases, comprising ten aspergillosis cases, three cases of paracoccidioidomycosis and one case each of histoplasmosis and cryptococcosis. Among the patients with pulmonary mycoses, 86.7% were former tuberculosis patients. The most significant clinical characteristics associated with pulmonary mycoses were cavity-shaped lung injuries, prolonged chronic cough and hemoptysis. Conclusions Our study confirmed the high prevalence of pulmonary mycoses in smear-negative tuberculosis patients in the Brazilian Amazon.

Details

ISSN :
11301406
Volume :
38
Database :
OpenAIRE
Journal :
Revista Iberoamericana de Micología
Accession number :
edsair.doi.dedup.....a7ad633f98cd49a5177f10be3b620a63
Full Text :
https://doi.org/10.1016/j.riam.2020.12.004