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Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior
- Source :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Nature, 2019.
-
Abstract
- Masking is a direct behavioral response to environmental changes and plays an important role in the temporal distribution of activity. However, the mechanisms responsible for masking remain unclear. Here we identify thermosensors and a possible neural circuit regulating temperature-dependent masking behavior in mice. Analysis of mice lacking thermosensitive transient receptor potential (TRP) channels (Trpv1/3/4 and Trpm2/8) reveals that temperature-dependent masking is impaired in Trpm2- and Trpm8-null mice. Several brain regions are activated during temperature-dependent masking, including the preoptic area (POA), known as the thermoregulatory center, the suprachiasmatic nucleus (SCN), which is the primary circadian pacemaker, the paraventricular nucleus of the thalamus (PVT), and the nucleus accumbens (NAc). The POA, SCN, PVT are interconnected, and the PVT sends dense projections to the NAc, a key brain region involved in wheel-running activity. Partial chemical lesion of the PVT attenuates masking, suggesting the involvement of the PVT in temperature-dependent masking behavior.
- Subjects :
- 0301 basic medicine
Masking (art)
Male
endocrine system
Thalamus
lcsh:Medicine
TRPM Cation Channels
TRPV Cation Channels
Nucleus accumbens
Article
Nucleus Accumbens
03 medical and health sciences
Transient receptor potential channel
Mice
0302 clinical medicine
Neural Pathways
medicine
TRPM8
Animals
lcsh:Science
Neurons
Multidisciplinary
Suprachiasmatic nucleus
Chemistry
lcsh:R
Temperature
Brain
Preoptic Area
Circadian Rhythm
Preoptic area
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
nervous system
lcsh:Q
Female
Suprachiasmatic Nucleus
Nucleus
Neuroscience
Perceptual Masking
030217 neurology & neurosurgery
Paraventricular Hypothalamic Nucleus
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....a7d5103d9c047ace0551d7fef28b05d9