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Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius)

Authors :
Ki Hyun Kim
Su Cheol Baek
Jae Cheol Lee
Changhyun Pang
Jin-Chul Kim
Bum Soo Lee
Tae Su Jang
Jae Sik Yu
Sang Ah Yi
Source :
Biomedicines, Vol 9, Iss 91, p 91 (2021), Biomedicines, Volume 9, Issue 1
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Safflower (Carthamus tinctorius) is an annual herb belonging to the Compositae family<br />it has a history of use as a food colorant, dye, and medicine in oriental countries. LC-MS-UV-based chemical analysis of extract of the florets of C. tinctorius led to the isolation of two new C10-polyacetylene glycosides, (8Z)-decaene-4,6-diyne-1,10-diol-1-O-&beta<br />d-glucopyranoside (1) and (8S)-deca-4,6-diyne-1,8-diol-1-O-&beta<br />d-glucopyranoside (2), together with five known analogs (3&ndash<br />7). The structures of the new compounds were determined by using 1D and 2D NMR spectroscopic data and HR-MS data, as well as chemical transformations. Of compounds 1&ndash<br />7, compounds 2, 3, and 4 inhibited the adipogenesis of 3T3-L1 preadipocytes, whereas compounds 1 and 6 promoted adipogenesis. Compounds 2, 3, and 4 also prevented lipid accumulation through the suppression of the expression of lipogenic genes and the increase of the expression of lipolytic genes. Moreover, compounds 3 and 4 activated AMPK, which is known to facilitate lipid metabolism. Our findings provide a mechanistic rationale for the use of safflower-derived polyacetylene glycosides as potential therapeutic agents against obesity.

Details

Language :
English
ISSN :
22279059
Volume :
9
Issue :
91
Database :
OpenAIRE
Journal :
Biomedicines
Accession number :
edsair.doi.dedup.....a7ecdf3406b30168294ade8b771dcceb