Back to Search
Start Over
Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius)
- Source :
- Biomedicines, Vol 9, Iss 91, p 91 (2021), Biomedicines, Volume 9, Issue 1
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Safflower (Carthamus tinctorius) is an annual herb belonging to the Compositae family<br />it has a history of use as a food colorant, dye, and medicine in oriental countries. LC-MS-UV-based chemical analysis of extract of the florets of C. tinctorius led to the isolation of two new C10-polyacetylene glycosides, (8Z)-decaene-4,6-diyne-1,10-diol-1-O-&beta<br />d-glucopyranoside (1) and (8S)-deca-4,6-diyne-1,8-diol-1-O-&beta<br />d-glucopyranoside (2), together with five known analogs (3&ndash<br />7). The structures of the new compounds were determined by using 1D and 2D NMR spectroscopic data and HR-MS data, as well as chemical transformations. Of compounds 1&ndash<br />7, compounds 2, 3, and 4 inhibited the adipogenesis of 3T3-L1 preadipocytes, whereas compounds 1 and 6 promoted adipogenesis. Compounds 2, 3, and 4 also prevented lipid accumulation through the suppression of the expression of lipogenic genes and the increase of the expression of lipolytic genes. Moreover, compounds 3 and 4 activated AMPK, which is known to facilitate lipid metabolism. Our findings provide a mechanistic rationale for the use of safflower-derived polyacetylene glycosides as potential therapeutic agents against obesity.
- Subjects :
- AMPK
food.ingredient
Medicine (miscellaneous)
01 natural sciences
General Biochemistry, Genetics and Molecular Biology
Polyacetylene
chemistry.chemical_compound
food
Carthamus tinctorius
lcsh:QH301-705.5
chemistry.chemical_classification
biology
010405 organic chemistry
3T3-L1 preadipocytes
Carthamus
Glycoside
Lipid metabolism
biology.organism_classification
0104 chemical sciences
polyacetylene glycosides
010404 medicinal & biomolecular chemistry
Biochemistry
chemistry
lcsh:Biology (General)
Adipogenesis
Herb
safflower
Two-dimensional nuclear magnetic resonance spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Volume :
- 9
- Issue :
- 91
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....a7ecdf3406b30168294ade8b771dcceb