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Fish Oil Suppresses Body Fat Accumulation in Zebrafish
- Source :
- Zebrafish. 15:27-32
- Publication Year :
- 2018
- Publisher :
- Mary Ann Liebert Inc, 2018.
-
Abstract
- Zebrafish is an often used model of vertebrate lipid metabolism. In this article, we examined the effects of diets rich in fish oil, a dietary fat that has been shown to have antiobesity effects in mammals, or lard on body fat accumulation in zebrafish. Adult female zebrafish were fed a high-fat diet containing 20% (w/w) fish oil or lard for 4 weeks. Fish in the fish oil diet group had less body fat accumulation compared with those in the lard diet group. In the intestine, expression of genes for the alpha (hadhaa) and beta (hadhb) subunits of the beta-oxidation enzyme hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase was significantly increased in the fish oil diet group compared with the lard diet group (p 0.05). In the liver, expression of the gene for fatty acid synthase (fasn) was significantly decreased in the fish oil diet group compared with the lard diet group (p 0.05). These results suggest that the mechanisms underlying the antiobesity effect of fish oil are similar in zebrafish and mammals.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Alpha (ethology)
03 medical and health sciences
Fish Oils
Internal medicine
medicine
Animals
Zebrafish
030109 nutrition & dietetics
biology
Thiolase
food and beverages
Lipid metabolism
Zebrafish Proteins
Lipid Metabolism
biology.organism_classification
Fish oil
medicine.disease
Dietary Fats
Obesity
Fatty acid synthase
030104 developmental biology
Endocrinology
Adipose Tissue
Gene Expression Regulation
biology.protein
Animal Science and Zoology
HADHB
Developmental Biology
Subjects
Details
- ISSN :
- 15578542 and 15458547
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Zebrafish
- Accession number :
- edsair.doi.dedup.....a7f56e8a983c52d8d4be028020c82f37