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Characterization of the human T cell response against the neuronal protein synapsin in patients with multiple sclerosis
- Source :
- Journal of Neuroimmunology. 115:176-181
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Although multiple sclerosis (MS) is considered primarily as a demyelinating disease, neuronal damage is abundant and correlates with the neurological deficit. Therefore, we investigated the frequency and characteristics of human T cells specific for synapsin-a neuronal protein highly conserved among species. Synapsin specific T cell responses were detected at a frequency similar to that of MBP specific T cells in MS patients, one patient with acute demyelinating encephalomyelitis (ADEM) and controls. Long-term T cell lines specific for synapsin exhibited a CD3(+), CD4(+), CD8(-) phenotype and produced high amounts of tumor-necrosis-factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) after antigen specific stimulation, whereas lymphotoxin (LT), interleukin-4 (IL-4) and interleukin-10 (IL-10) were detectable in smaller quantities.
- Subjects :
- Multiple Sclerosis
CD3 Complex
T-Lymphocytes
T cell
Encephalomyelitis
Immunology
Dose-Response Relationship, Immunologic
Cell Line
Immunophenotyping
Interferon-gamma
03 medical and health sciences
0302 clinical medicine
medicine
Demyelinating disease
Humans
Immunology and Allergy
Lymphotoxin-alpha
030304 developmental biology
0303 health sciences
biology
Tumor Necrosis Factor-alpha
Multiple sclerosis
Encephalomyelitis, Acute Disseminated
Myelin Basic Protein
Synapsin
Synapsins
medicine.disease
Molecular biology
Interleukin-10
Myelin basic protein
medicine.anatomical_structure
Lymphotoxin
nervous system
Neurology
Acute Disease
CD4 Antigens
biology.protein
Interleukin-4
Neurology (clinical)
030217 neurology & neurosurgery
CD8
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....a7f7b0a4b8268c0ac4b4618b6e5f9ba8