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Analysis of the three common mutations in the CARD15 gene (R702W, G908R and 1007fs) in South African colored patients with inflammatory bowel disease
- Source :
- Molecular and Cellular Probes. 19:278-281
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- The caspase recruitment domain-containing protein 15 gene (CARD15) was recently identified as an important susceptibility gene for Crohn's disease (CD). The purpose of this study was to assess the likelihood that the three most common CARD15 mutations, R702W, G908R and 1007fs, contribute to inflammatory bowel disease (IBD) susceptibility in the South African colored population. The study cohort included 76 IBD patients, 41 with CD and 35 with ulcerative colitis (UC), and 100 population-matched controls. Mutations R702W, G908R and 1007fs were present at relatively low frequencies (
- Subjects :
- Male
Genotype
DNA Mutational Analysis
Population
Nod2 Signaling Adaptor Protein
Black People
Biology
Inflammatory bowel disease
South Africa
Gene Frequency
NOD2
medicine
Humans
education
Molecular Biology
Allele frequency
education.field_of_study
Intracellular Signaling Peptides and Proteins
Cell Biology
Inflammatory Bowel Diseases
medicine.disease
Ulcerative colitis
digestive system diseases
Genotype frequency
Immunology
Population study
Female
Subjects
Details
- ISSN :
- 08908508
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Probes
- Accession number :
- edsair.doi.dedup.....a81beeaa654e4dcbce228e58f1bdd9b2
- Full Text :
- https://doi.org/10.1016/j.mcp.2005.03.001