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Analysis of the three common mutations in the CARD15 gene (R702W, G908R and 1007fs) in South African colored patients with inflammatory bowel disease

Authors :
Louise Warnich
Maritha J. Kotze
Trevor A. Winter
Monique G. Zaahl
Source :
Molecular and Cellular Probes. 19:278-281
Publication Year :
2005
Publisher :
Elsevier BV, 2005.

Abstract

The caspase recruitment domain-containing protein 15 gene (CARD15) was recently identified as an important susceptibility gene for Crohn's disease (CD). The purpose of this study was to assess the likelihood that the three most common CARD15 mutations, R702W, G908R and 1007fs, contribute to inflammatory bowel disease (IBD) susceptibility in the South African colored population. The study cohort included 76 IBD patients, 41 with CD and 35 with ulcerative colitis (UC), and 100 population-matched controls. Mutations R702W, G908R and 1007fs were present at relatively low frequencies (

Details

ISSN :
08908508
Volume :
19
Database :
OpenAIRE
Journal :
Molecular and Cellular Probes
Accession number :
edsair.doi.dedup.....a81beeaa654e4dcbce228e58f1bdd9b2
Full Text :
https://doi.org/10.1016/j.mcp.2005.03.001