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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
- Source :
- Nature Genetics, 42, 11, pp. 978-984, Nature genetics, Nature Genetics, 42, 978-984, Recercat. Dipósit de la Recerca de Catalunya, instname
- Publication Year :
- 2010
-
Abstract
- We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.
- Subjects :
- Male
Arylamine N-Acetyltransferase
Chromosomes, Human, Pair 22
Genome-wide association study
Aetiology, screening and detection [ONCOL 5]
medicine.disease_cause
Genome-wide association studies
Risk Factors
genome-wide association
bladder cancer
Psychology
Genetics
Sex Characteristics
Incidence
Bladder cancer
Smoking
Chromosome Mapping
Single Nucleotide
Tag SNP
Europe
Chromosomes, Human, Pair 2
Pair 2
Female
Human
Locus (genetics)
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Risk Assessment
Chromosomes
Article
Molecular epidemiology [NCEBP 1]
Translational research [ONCOL 3]
medicine
Humans
Family
Genetic Predisposition to Disease
Polymorphism
Pair 18
Pair 22
Genome-Wide Association Study
Neoplasm Staging
Spain
United States
Urinary Bladder Neoplasms
Cancer
Chromosome
medicine.disease
Evaluation of complex medical interventions [NCEBP 2]
Carcinogenesis
Chromosomes, Human, Pair 18
Subjects
Details
- Language :
- English
- ISSN :
- 15461718 and 10614036
- Volume :
- 42
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Nature genetics
- Accession number :
- edsair.doi.dedup.....a82b4e6e7d14d613bad4d435b9cb1b06