Back to Search
Start Over
pH and Temperature Responsive Polymeric Micelles and Polymersomes by Self-Assembly of Poly[2-(dimethylamino)ethyl methacrylate]-b-Poly(glutamic acid) Double Hydrophilic Block Copolymers
pH and Temperature Responsive Polymeric Micelles and Polymersomes by Self-Assembly of Poly[2-(dimethylamino)ethyl methacrylate]-b-Poly(glutamic acid) Double Hydrophilic Block Copolymers
- Source :
- Langmuir, Langmuir, American Chemical Society, 2010, 26 (13), pp.10546-10554. ⟨10.1021/la1005693⟩, Langmuir, 2010, 26 (13), pp.10546-10554. ⟨10.1021/la1005693⟩
- Publication Year :
- 2010
- Publisher :
- American Chemical Society (ACS), 2010.
-
Abstract
- International audience; The aqueous solution behavior of novel polypeptide-based double hydrophilic block copolymers (DHBCs), namely, poly[2-(dimethylamino)ethyl methacrylate]-b-poly(glutamic acid) (PDMAEMA-b-PGA), exhibiting pH- and temperature-responsiveness is presented using a combination of scattering techniques (light and neutron) and transmission electron microscopy. Close to the isoelectric point (IEP), direct or inverse electrostatic polymersomes are generated by electrostatic interactions developing between the two charged blocks and driving the formation of the hydrophobic membrane of the polymersomes, with the latter being stabilized in water by uncompensated charges. Under basic conditions, that is, when PDMAEMA is uncharged, the thermosensitivity of the DHBCs relates to the lower critical solution temperature (LCST) behavior of PDMAEMA around 40 degrees C. As a consequence, at pH = 11 and below this LCST, free chains of DHBC unimers are evidenced, while above the LCST the hydrophobicity of PDMAEMA drives the self-assembly of the DHBCs in a reversible manner. In this case, spherical polymeric micelles or polymersomes are obtained, depending on the PGA block length. These possibilities of variation in size and shape of morphologies that can be achieved as a function of temperature and/or pH variations open new routes in the development of multiresponsive nanocarriers for biomedical applications.
- Subjects :
- CROSS-LINKING
Polymers
Glutamic Acid
02 engineering and technology
010402 general chemistry
Methacrylate
01 natural sciences
Micelle
Lower critical solution temperature
GENE DELIVERY
Microscopy, Electron, Transmission
AQUEOUS-SOLUTIONS
Polymer chemistry
Electrochemistry
Copolymer
Nanotechnology
Scattering, Radiation
General Materials Science
POLY(2-VINYLPYRIDINIUM)-BLOCK-POLY(ETHYLENE OXIDE)
DRUG-DELIVERY
Micelles
Spectroscopy
Aqueous solution
Chemistry
Temperature
POLYPEPTIDE DIBLOCK COPOLYMERS
COACERVATE CORE MICELLES
Surfaces and Interfaces
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
Condensed Matter Physics
Nanostructures
0104 chemical sciences
Nylons
[CHIM.POLY]Chemical Sciences/Polymers
Isoelectric point
NEUTRON-SCATTERING
Polymersome
Methacrylates
CLICK CHEMISTRY
Self-assembly
0210 nano-technology
POLYION COMPLEX MICELLES
Subjects
Details
- ISSN :
- 15205827 and 07437463
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Langmuir
- Accession number :
- edsair.doi.dedup.....a841bf42461ea0a354d926bfb1030138
- Full Text :
- https://doi.org/10.1021/la1005693