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Increased risk of stroke in patients with chronic kidney disease after recurrent hypoglycemia
- Source :
- Neurology. 83:686-694
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- In this study, we aimed to investigate the effect of hypoglycemia on cardiovascular outcomes in a sample of patients with chronic kidney disease (CKD).Information about study participants was extracted from the National Health Insurance Research Database of Taiwan for the years 1998 through 2008. We conducted this retrospective cohort study of patients with CKD, with and without hypoglycemia, to evaluate the risk of overall mortality and cardiovascular complications including stroke, coronary heart disease, and congestive heart failure in both groups.This study included 46,135 patients with CKD, of whom 2,117 (4.59%) were hospitalized and had hypoglycemia. Results of multivariate Cox proportional hazard regression analyses indicated that stroke (hazard ratio [HR] = 1.62, 95% confidence interval [CI] = 1.29-2.03), coronary heart disease (HR = 1.25, 95% CI = 1.00-1.57), congestive heart failure (HR = 1.49, 95% CI = 1.13-1.98), and death (HR = 2.53, 95% CI = 1.99-3.21) were associated with hypoglycemia in patients with CKD. Recurrent episodes of hypoglycemia were associated with a higher risk of death (HR = 33.0, 95% CI = 22.3-48.8 for2 episodes, p for trend0.0001), and a similar trend was observed for other multiple cardiovascular events. We observed an increased risk of stroke and overall mortality in patients with hypoglycemia compared to those without hypoglycemia, regardless of whether the patient had diabetes.CKD was associated with a higher risk of stroke and mortality in patients with hypoglycemia. Recurrent hypoglycemia considerably increased the risk of stroke and overall mortality in patients with CKD regardless of whether they had diabetes. These results suggest that hypoglycemia has a crucial role in stroke and death in patients with CKD.
- Subjects :
- Male
Risk
medicine.medical_specialty
Recurrent hypoglycemia
Taiwan
Hypoglycemia
Cohort Studies
Diabetes Complications
Recurrence
Risk Factors
Internal medicine
Diabetes Mellitus
medicine
Humans
Renal Insufficiency, Chronic
Stroke
Retrospective Studies
Heart Failure
business.industry
Hazard ratio
Retrospective cohort study
medicine.disease
Heart failure
Female
Neurology (clinical)
business
Cohort study
Kidney disease
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....a85aac5fefb2121e7afa3c3c889ecc61