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A prospective randomized double-blind study of pain control by topical calcium channel blockers versus placebo after Milligan–Morgan hemorrhoidectomy
- Source :
- International Journal of Colorectal Disease. 33:895-899
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Post-hemorrhoidectomy pain is significantly associated with a hypertonicity of the internal anal sphincter. We evaluated the effects of topical diltiazem, a calcium channel blocker, in reducing pain after hemorrhoidectomy. Purpose of our study was to determine difference in extent of pain control by application of topical calcium channel blocker (diltiazem 2%) versus placebo ointment. This was a prospective randomized double-blind clinical study conducted at Sawai Man Singh Hospital, Jaipur, from May 2016 to May 2017. Sixty patients, who had undergone hemorrhoid, were randomly assigned to receive 2% diltiazem ointment (n = 30) or a placebo ointment (n = 30) postoperatively. Ointments were applied to the perianal region three times daily for 7 days. Pain scores were recorded using visual analog scale at 6, 24, and 48 h and seventh day postoperatively and number of analgesic doses consumed by patients in the first 3 days. Patients using the diltiazem ointment had significantly less pain and greater benefit than those in the placebo group throughout the first postoperative week (p
- Subjects :
- Adult
Hemorrhoidectomy
Male
medicine.medical_specialty
Adolescent
Visual analogue scale
medicine.drug_class
Administration, Topical
Analgesic
India
Calcium channel blocker
Placebo
Hemorrhoids
Internal anal sphincter
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Internal medicine
medicine
Humans
Prospective Studies
Diltiazem
Pain, Postoperative
business.industry
Calcium channel
Gastroenterology
Middle Aged
Hepatology
Calcium Channel Blockers
Treatment Outcome
030220 oncology & carcinogenesis
Anesthesia
Female
030211 gastroenterology & hepatology
business
medicine.drug
Subjects
Details
- ISSN :
- 14321262 and 01791958
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- International Journal of Colorectal Disease
- Accession number :
- edsair.doi.dedup.....a86b2dd318bdbb1eb22ebf8e049878a0