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Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database

Authors :
James Huang
Ann Christine Catlin
Nicolas Girard
Frank C. Detterbeck
Sumudinie Fernando
John R. Rutledge
Robert Korst
Source :
The Annals of Thoracic Surgery. 104:1815-1820
Publication Year :
2017
Publisher :
Elsevier BV, 2017.

Abstract

Background Positron emission tomography may have a role in the pretreatment workup of patients with thymic malignancies. This study was undertaken to determine the utility of the maximum standardized uptake value (SUVmax) in predicting histologic type and tumor stage in a large cohort of thymic epithelial tumors. Methods The large, multiinstitutional, prospective database of The International Thymic Malignancy Interest Group (ITMIG) was queried for the use of positron emission tomography in the pretreatment workup of patients with thymic tumors. Data analyzed included demographics, SUVmax, histologic tumor type, and tumor stage. The distribution of SUVmax according to histologic type and Masaoka-Koga pathologic stage was determined, and the ability of SUVmax to predict these two variables was calculated using analysis of receiver operating characteristic curves. Results Since 2012, data from 926 patients with thymic malignancies were entered into the ITMIG prospective database, of which 154 had a reported value for SUVmax. The area under the receiver operating characteristic curve for SUVmax in predicting histologic type and pathologic stage was 0.79 (95% confidence interval, 0.70 to 0.88; p Conclusions Positron emission tomography has utility in predicting clinicopathologic features of thymic malignancies. These results may have clinical application in the pretreatment workup of patients with these rare tumors.

Details

ISSN :
00034975
Volume :
104
Database :
OpenAIRE
Journal :
The Annals of Thoracic Surgery
Accession number :
edsair.doi.dedup.....a878dfb0094602d2091b68d8d4f25698
Full Text :
https://doi.org/10.1016/j.athoracsur.2017.06.053