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Assessment of Wheezing Frequency and Viral Etiology on Childhood and Adolescent Asthma Risk
- Publication Year :
- 2016
-
Abstract
- Rationale: We have previously reported that early rhinovirus (RV) wheezing illnesses are the most robust predictor of asthma development at age 6 years in high-risk children in the Childhood Origins of ASThma (COAST) birth cohort study. We sought to assess the role of etiology and frequency of wheezing illnesses in asthma risk from ages 6 to 13 years. Methods: A total of 259 children were followed prospectively to age 6 years, and 217 were followed to age 13 years. A generalized additive logistic regression model (GAM) of asthma was fit for asthma diagnosed at ages 6, 8, 11, 13 years, with smooth terms for number of RV wheezing illnesses, number of non-RV wheezing illnesses, and their interaction. In the absence of significant interaction the main effect p-values are reported. Results: The number of RV wheezing episodes in early childhood was significantly associated with asthma at all ages (6 years: p
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Adolescent
Rhinovirus
Immunology
medicine.disease_cause
Logistic regression
Respirovirus Infections
Article
Respirovirus
03 medical and health sciences
0302 clinical medicine
Immunology and Allergy
Medicine
Humans
030212 general & internal medicine
Early childhood
Respiratory sounds
Child
Viral etiology
Asthma
Respiratory Sounds
Picornaviridae Infections
medicine.diagnostic_test
business.industry
medicine.disease
030228 respiratory system
Etiology
Female
business
Risk assessment
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a89114d9663bf102981a41bd8fea8abd